Article on "Plasma free amino acid profiling of five types of cancer patients and its
application for early detection"
Published in Online Scientific Journal PLoS ONE
TOKYO, September 8, 2011 - Ajinomoto Co., Inc. (Ajinomoto), together with a group led by Dr. Yohei Miyagi of the Molecular Pathology and Genetics Division and Dr. Naoyuki Okamoto of the Cancer Prevention and Control Division of Kanagawa Cancer Center Research Institute, has been conducting research on alterations in the plasma amino acid profiles in the cancer patients with five types of cancer (lung, gastric, colorectal, breast and prostate cancer). In a large-scale, multicenter clinical trial, Miyagi, et al. found that the plasma amino acid profiles in cancer patients were significantly different from those in healthy individuals, that these differences were recognizable even in the patients with early stage cancer, and that multivariate analysis of plasma amino acid profiles was potentially applicable in early detection of cancer.
These findings were published on September 7, 2011 in the online journal PLoS ONE.*
Ajinomoto has developed "AminoIndex Technology" that statistically analyzes and indexes alterations in the plasma amino acid profiles to clarify health condition and disease risk. Amino acid concentration in the blood is regulated strictly by the body's homeostatic functions, but numerous reports mentioned that this balance was influenced by various diseases, and altered compared to healthy individuals.1
Summary of the Article
Alteration of plasma amino acid profiles of cancer patients have been reported previously, but all of these reports were limited to small-scale studies. This study collected subjects on a larger scale, including early-stage cancer patients, from multiple medical institutes. Case-control studies were then conducted to verify whether plasma amino acid profiles of cancer patients could be discriminated from those of control group statistically.
In the study, plasma amino acid profiles were compared among 928 cancer patients, consisting of 130-200 patients for each type of cancer, and a total of 4,618 healthy subjects comprising 650-1,000 controls for each type of cancer.
The findings showed that
Figure Changes in Amino Acid Concentration Balance in Five Types of Cancer Patients
By applying the knowledge obtained from this study, "AminoIndex Technology" has potential for use in early detection of multiple types of cancer in blood samples with a high degree of precision and convenience. This will increase opportunities for early treatment of cancer which will lead to fewer cancer deaths, the leading cause of death in Japan, and lower medical care expenses related to cancer treatment. In addition to extending the applicability of "AminoIndex Technology" to other diseases, Ajinomoto also plans to determine the mechanism that alterations in plasma amino acid profiles observed in the cancer patients and will conduct further research, including cohort studies.3
Title of the Study and Authors
Plasma free amino acid profiling of five types of cancer patients and its application for early detection
Yohei Miyagi*1, Masahiko Higashiyama2, Akira Gochi3, Makoto Akaike1, Takashi Ishikawa4, Takeshi Miura1, Nobuhiro Saruki5, Etsuro Bando6, Hideki Kimura7, Fumio Imamura2, Masatoshi Moriyama8, Ichiro Ikeda9, Akihiko Chiba1, Fumihiro Oshita1, Akira Imaizumi10, Hiroshi Yamamoto10, Hiroshi Miyano10, Katsuhisa Horimoto11, Osamu Tochikubo12, Toru Mitsushima13, Minoru Yamakado14, and Naoyuki Okamoto1
*1. Kanagawa Cancer Center, 2. Osaka Medical Center for Cancer and Cardiovascular Diseases,
3. Okayama University Hospital, 4. Yokohama City University Medical Center, 5. Gunma Prefectural Cancer Center, 6. Shizuoka Prefectural Cancer Center, 7. Chiba Prefectural Cancer Center, 8. Yokohama Municipal Citizen's Hospital, 9. Yokohama Minami Kyosai Hospital, 10. Institute for Innovation, Ajinomoto Co., Inc., 11. National Institute of Advanced Industrial Science and Technology, 12. Kanagawa Health Service Association, 13. Kameda Medical Center Makuhari, 14. Mitsui Memorial Hospital
Ajinomoto is a global manufacturer of high-quality seasonings, processed foods, beverages, amino acids, pharmaceuticals and specialty chemicals. For many decades Ajinomoto has contributed to food culture and human health through wide-ranging application of amino acid technologies. Today, the company is becoming increasingly involved with solutions for improved food resources, human health and global sustainability.
Founded in 1909 and now operating in 25 countries, Ajinomoto had net sales of JPY 1,170.8 billion (USD 12.8 billion) in fiscal 2010. For more about Ajinomoto (TYO: 2802), visit www.ajinomoto.com.
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Ajinomoto Co., Inc. Public Communications Department; email@example.com