Ajinomoto Amino Acid Research Program

Ajinomoto Co., Inc. is pleased to announce the recipients of the 3ARP grant
                                                 (2012, 2011, 2010, 2009, 2008, 2007, 2006, 2005.)

2012 Recipients

  Srinivasan Dasarathy (The Cleveland Clinic Foundation)
  • Mechanisms of sarcopenia in cirrhosis
  Rajavel Elango  (The University of British Columbia and Children's & Women's Health Centre of British Columbia Branch)
  • Protein requirements in malnourished school-aged Indian children determined using the indicator amino acid oxidation technique
  Yuzo Ninomiya (Kyusyu University)
  • Modulation of sensitivity of oral and gut amino acid taste sensors by orexigenic and anorexigenic mediators
  Gary Schwartz (Albert Einstein College of Medicine of Yeshiva University)
  • Brainstem leucine sensing in the control of obesity and diabetes
  Yoshiharu Shimomura (Nagoya University)
  • Molecular mechanism responsible for regulation of branched-chain amino acid (BCAA) catabolism by the branched-chain α-keto acid dehydrogenase kinase (BDK)

2011 Recipients

  Eugene Delay (University of Vermont)
  • L-amino acid taste activation of the NST
  Michael S. Kilberg (University of Florida College of Medicine)
  • Amino Acid Limitation of Mouse Embryonic Stem Cells
  Bettina Mittendorfer (Washington University School of Medicine)
  • Calorie restriction with essential amino acid supplementation in postmenopausal women Robert Grange (Virginia Polytechnic Institute and State University)
  Robert Grange (Virginia Polytechnic Institute and State University)
  • Signal pathways by which Branched Chain Amino Acids (BCAA) modulate dystrophic skeletal muscle protein turnover to improve strength and endurance.
  David Bendahan (CEMEREM)
  • Metabolic and functional effects of branch chain amino acids in eccentrically-damaged exercising muscle: A non invasive MRS and MRI study in humans
  Mary-Elizabeth Patti (Joslin Diabetes Center, Inc.)
  • Effects of Betaine Supplementation on the Prevention and Treatment of Insulin Resistance
  Seiji Nishino (Stanford University Sleep Research Center)
  • Changes in Amino Acid Metabolism Associated with Sleep Changes.
  Philip Atherton (University of Nottingham)
  • Modulation of muscle protein synthesis (MPS) by essential amino acids (EAA): exploring the "muscle-full" phenomenon in humans

2010 Recipients

  Satish Kalhan (Cleveland Clinic Lerner Research Institute)
  • Creatine metabolism in humans: effect of amino acid supplement
  Yoshikatsu Kanai (Osaka University)
  • Identification and characterization of plasma membrane amino acid receptors mobilizing Ca2+ and regulating cell growth and metabolism
  Stefano Sforza (University of Parma)
  • Identification of microrganisms and conditions for optimal bioproduction of gamma-glutamyl aminoacids as new flavouring agents
  Michael Tordoff (Monell Chemical Senses Center)
  • Mechanism of glutamate's antiobesity effect
  Francois Verrey (University of Zurich)
  • The role of Blood-Brain barrier in establishing and maintaining brain interstitial fluid amino acid homeostasis
  Kevin Yarasheski (Washington University School of Medicine)
  • Myocardial branched chain amino acid metabolism in human disease
  Daniela Cota (INSERM U862, University Bordeaux 2)
  • Metabolic effects of leucine supplementation on the prevention and treatment of diet-induced obesity

2009 Recipients

  Ronald O. Ball (University of Alberta)
  • Dynamic aspects of amino acid metabolism in pregnant sows
  John D. Boughter Jr. (University of Tennessee Health Science Center)
  • Central pathways for amino acid taste and preference in mice
  Dominique Darmaun (University of Nantes and INRA)
  • Can citrulline enhance protein synthesis and growth in intrauterine growth restriction?
  Steven D. Munger (University of Maryland School of Medicine)
  • Modulation of umami sensing in the taste and digestive systems
  Anthony Sclafani (Brooklyn College of The City University of New York)
  • Flavor conditioning by glutamate in the gut
  Roger Gutierrez-Juarez (Albert Einstein College of Medicine)
  • Cross-talk between brain amino acid metabolism and liver glucose homeostasis
  René Koopman (The University of Melbourne)
  • Citrulline as a pharmaco-nutrient to attenuate muscle wasting

2008 Recipients

  John Ngai (U.C.Berkeley)
  • Identification of Amino Acid Ligands for Olfactory and Taste Receptors
  Gerard Karsenty (Columbia Univ.)
  • Amino acids as regulators of bone mass
  Janet Brunton (Memorial Univ. of Newfoundland, Young Investigator)
  • Dipeptides as Trophic Factors in the Gut
  Jochen Reiser (Massachusetts Gen. Hospital/Harvard Med. School, Young Investigator)
  • Amino acid metabolism in kidney podocytes as target for proteinuric kidney disease
  Thomas Finger (Univ. of Colorado)
  • Amino Acid Ingestion and Brain Activation in "Tasteless" Mice
  Sue C Kinnamon (Colorado State Univ.)
  • Glutamate: A tastant and a neurotransmitter in taste buds
  Douglas R. Cavener (The Penn. State Univ.)
  • Amino acid sensor GCN2 regulation of fat metabolism
  Naomi K. Fukagawa (Univ. of Vermont)
  • Synergistic Effects of the Branched Chain Amino Acids (BCAA) and Carnosine (CAR) Precursors on Exercise-induced Muscle Damage and Performance in Humans

2007 Recipients

  Tao Pan (The University of Chicago)
  • Amino Acids as Sensors and Regulators of Global Metabolic State
  Pengxiang She (Pennsylvania State University)
  • Mechanisms by Which Mice Lacking BCAA Catabolism Improve Glucose Homeostasis
  Robert A. Harris (Indiana University)
  • Exploratory Study on the Metabolic and Neurological Defects Induced by Chronically Reduced BCAA Levels.
  Charles C. Horn (Monell Chemical Senses Center)
  • Mechanisms for Detection of Amino Acids by Sensory Nerve Fibers of the Gut
  Teresa A. Davis (Baylor College of Medicine)
  • Parenteral and Enteral Leucine as a Nutrient Signal to Stimulate Protein Synthesis in Neonates
  Scot R. Kimball (Pennsylvania State University)
  • Leucine-Induced Assembly of an Activated Subcellular mTOR Signaling Complex

2006 Recipients

  Leticia Castillo (Baylor College of Medicine)
  • Nutrition and functional requirement of methionine in septic children
  Yoshinori Moriyama (Okayama University)
  • Vesicular glutamate transporter: Molecular architecture and physiological roles in metabolic regulation
  Johannes Van Goudoever (Erasmus MC-Sophia M)
  • Optimizing nutrition for infants with an impaired gut function
  Douglas Burrin (USDA-ARS, Children's Nutrition Research Center)
  • Vasoactive and tropic actions of enteral arginine in the neonatal porcine intestine
  Pierre Fafournoux (Institut National de la Recherche Agronomique(INRA))
  • Role of the GCN2 kinase in the feeding behavior response to variations in dietary amino acid supply
  John Fernstrom (University of Pittsburgh)
  • An exploratory biochemical study to assess if serotonin & catecholamine neurons in brain respond to chronic, diet-related changes in plasma amino acids
  Jonathan Powell (The Johns Hopkins University)
  • Regulation of T-cell activation and tolerance by branch chain amino acids
  Christopher Proud(University of British Columbia)
  • Identification and characterization of cellular components involved in the control of mTOR signaling by amino acids
  Gozoh Tsujimoto (Kyoto University)
  • Identification and characterization on physiological roles of receptor(s) to nutrients in gastro-intestinal tract

2005 Recipients

  Charles A. Stanley (The Children's Hospital, Univ. of Pennsylvania)
  • Signaling roles of amino acids in pancreatic insulin secretion.
  Alexander A. Bachmanov (Monell Chemical Senses Center)
  • Genetics of amino acid taste and appetite in mice.
  K. Sreekumaran Nair (Mayo Clinic)
  • BCAA as stimulant of muscle mitochondrial function in elderly people.
  Anura Kurpad (Inst. of Population Health & Clinical Research)
  • Long term generous lysine intake in well- and undernourished humans: its effect on muscle mass/body composition, and protein and glucose metabolism.
  Jiyang Cai (Vanderbilt Eye Inst.)
  • Extracellular cyst(e)ine regulation of cell survival pathways in human retinal pigment epithelial cells.
  Christopher M. Anderson (St. Bonifice Hospital Res. Center, Univ. of Manitoba)
  • Role of astrocyte D-serine in neuronal excitotoxity.
  Michael J. Rennie (Univ. of Nottingham)
  • Do amino acids have specific anabolic effects on human bone collagen synthesis?
  Carla J. Aldrich, PhD (Indiana Univ., School of Medicine, Evansville Center)
  • Reconstitution of immune responses by feeding the essential amino acid (EAA) leucine in normal mice or mice lacking fundctional Gcn2 eIF2 kinase.