Contributing to advanced pharmaceuticals and medicines, and to healthcare, using cutting-edge bioscience and fine chemical technology
The Ajinomoto Group has unparalleled expertise in research on amino acid metabolism and functional analysis, allowing it to provide unique solutions in the areas of pharmaceuticals, medical care, and healthcare.
The Group has been the leading producer of amino acids for pharmaceuticals since becoming the world's first producer of crystalline amino acids used as pharmaceutical production materials in 1956. Today the Group also focuses on biopharmaceutical manufacturing technologies.
Developing biopharmaceutical technologies
The Ajinomoto Group has been developing unique hybrid processes combining fermentation and chemical synthesis technologies and applying them to the development of pharmaceutical intermediates derived from amino and nucleic acids. These activities evolved into a bulk pharmaceutical intermediate supply business, later expanding into our very-own, unique biopharmaceutical manufacturing technologies and business. The Ajinomoto Group now provides the AJIPHASE® service business for contract manufacturing of oligonucleotides and peptides, and CORYNEX® for contract development and manufacturing of proteins, and AJICAP™ for contract development and manufacturing of antibody drug conjugates (ADCs).
For customers interested in biopharmaceutical manufacturing technologies
A unique protein/peptide expression system using Corynebacterium glutamicum for Biologics, Vaccine and other various use
AJINOMOTO own technology of a novel solution phase approach for Oligonucleotides and Peptides and fit to large scale production
Innovative site-specific conjugation technology to manufacture ADCs without genetic engineering of antibodies
AminoIndex Technology is the name of a screening technology for measuring the level of blood amino acids as an indicator of the state of health and possible disorders. This technology is the result of integrating high-level technologies for amino acid analysis and our cumulative findings from extensive research on amino acid metabolism. It embodies a new method of statistical analysis developed by the Ajinomoto Group to obtain a profile of amino acids in the blood, and this profile provides an indicator for screening for diseases and disorders. AminoIndex Technology applies statistical analysis of the differences between amino acid profiles of healthy individuals and those with a disorder. The development of AminoIndex® Cancer Screening (AICS®) was completed several years ago, and business development began in April 2011 and is ongoing. The AminoIndex® Metabolic Screening (AIMS®) for disorders closely related to lifestyle is at the advanced stage of development.
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Culture media for antibody production and iPS cells
The Ajinomoto Group applied its process technology for the production of high-purity amino acids to develop its serum-free ASF Medium. The applications of ASF medium have grown since its market launch in 1987 for animal cell culture and it is now widely used in Japan and overseas for the production of antibodies and other biopharmaceuticals and as a research reagent. In 2013, Ajinomoto Genexine Co., Ltd. was established in the Republic of Korea and a new plant was constructed there to produce this medium for pharmaceuticals and therapeutics used in biopharmaceutical production. In another key advance, Ajinomoto Co., Inc. has developed a new medium for regenerative medicine, and launched StemFit® AK02N for basic research in October 2015 in Japan.
Nutrition for the elderly and sports nutrition are important areas of research and development in the Ajinomoto Group, in recognition of the imminent social needs posed by an increasingly aging society in Japan and elsewhere, the rising cost of medical care, and the goal of maintaining health and preventing disease.
A key part of providing solutions in this area is directed towards understanding the safety and functionality of the Group's health-related amino acids and other materials, and to providing information on these findings together with the solutions. This understanding is based on the Group's advanced physiological, pharmacological, and nutritional research, amino acids production, fermentation technologies, and food processing technologies, together with understanding the nutritional and disease-related conditions of individuals.
We recently discovered that the amino acid glycine helps improve sleep quality. We also determined that leucine-rich essential amino acids can increase muscle protein synthesis and contributes to longer healthy life expectancy in the elderly. Furthermore, we have shown the "body-fat-burning" effect of the plant-derived material capsinoids, which are components of a non-pungent variety of pepper.
Health and nutrition are key values for products made from health-related materials. Enhancing the palatability is another key value, and the addition of materials for this purpose is crucial to their use. In this respect, in particular, our priority is improvement based on the voice of the customer.
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Ajinomoto Co., Inc. has established "Nutrition Policy" and "Nutrition Strategy Guideline" and is working to help consumers improve nutrition by offering a total package of information, products, and services based on a deep understanding of local conditions
Nutrition for the elderly
Our focus is on the nutritional functions of proteins and amino acids and their essential role in maintaining body structures and functions, together with investigations into the diets and food preferences of the elderly. Our goal is to find ways for the elderly to continue to lead healthy lives and savor the taste of everyday food.
The combination of advanced food-processing technologies, scientific knowledge, and pharmaceutical technologies allows the Ajinomoto Group to provide a diverse range of foods that promote health, including products such as a high-density liquid diet recognized for its functionality, taste, and convenience. Work in progress aimed at the elderly sector of society includes the development of food materials and products that will help the elderly maintain their health and independence.
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Using amino acids to reduce muscle loss and improve weakened immunity with aging
The increase in international sporting events is focusing interest on the physiological effects of amino acids, and particularly branched-chain amino acids (BCAAs), on muscles.
As a pioneer in research on the physiological effects of amino acids and on sports nutrition, we provide Amino Vital® GOLD and other product families that help maintain the health and condition of both professional and recreational athletes. We are committed to continuing product development based on advanced technologies and expertise in foods and amino acids, and backed by sports science, to contribute to the health and enjoyment of all who participate in sports and exercise.
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Amino Acids Help the Body Move and Function