Research Papers Research Papers

For over 100 years since the discovery of umami substances, we have explored the possibilities of amino acids. We carry out R&D activities in a wide range of fields centered around "AminoScience," an approach developed through many years of research on amino acids. See below for a list of academic papers where our results have been published.

  • Association between soup consumption and obesity: A systematic review with meta-analysis

    Physiology and Behavior, 2020, 225, 113103

  • Effects of capsinoid intake on brown adipose tissue vascular density and resting energy expenditure in healthy, middle‐aged adults: A randomized, double‐blind, placebo‐controlled study

    Nutrients, 2020, 12 (9), 2676, 1-14

  • Synthesis and Biological Evaluation of Antibody Drug Conjugates Based on an Antibody Expression System: Conamax

    ACS Omega, 2020, 5 (13), 7193-7200

  • Insight into Temperature Dependency and Design of Experiments towards Process Development for Cysteine-Based Antibody-Drug Conjugates

    ChemistrySelect, 2020, 5 (28), 8435-8439

  • Characterization of newly developed pepper cultivars (Capsicum chinense) ‘Dieta0011-0301’, ‘Dieta0011-0602’, ‘Dieta0041-0401’, and ‘Dieta0041-0601’ containing high capsinoid concentrations and a strong fruity aroma

    Bioscience, Biotechnology and Biochemistry, 2020, 84 (9), 1870-1885

  • Feeding rumen-protected lysine prepartum increases energy-corrected milk and milk component yields in Holstein cows during early lactation

    Journal of Dairy Science, 2020, 103 (12), 11386-11400

  • L-serine and EPA relieve chronic low-back and knee pain in adults: A randomized, double-blind, placebo-controlled trial

    Journal of Nutrition, 2020, 150 (9), 2278-2286

  • Structure–Activity Relationship Study of T1R2/T1R3 Positive Allosteric Modulators and Evaluation of Their Enhancing Effect on Various Sweeteners

    ChemistrySelect, 2020, 5 (30), 9457-9460

  • The effect of leucine-enriched essential amino acid supplementation on anabolic and catabolic signaling in human skeletal muscle after acute resistance exercise: A randomized, double-blind, placebo-controlled, parallel-group comparison trial

    Nutrients, 2020, 12 (8), 2421, 1-15

  • Characterization of the Corynebacterium glutamicum dehydroshikimate dehydratase QsuB and its potential for microbial production of protocatechuic acid

    PLoS ONE, 2020, 15 (8 August), e0231560

  • Histidine: A systematic review on metabolism and physiological effects in human and different animal species

    Nutrients, 2020, 12 (5), 1414

  • Dispensable amino acids, except glutamine and proline, are ideal nitrogen sources for protein synthesis in the presence of adequate indispensable amino acids in adult men

    Journal of Nutrition, 2020, 150 (9), 2398-2404

  • Nitrogen Balance in Female Japanese National Handball Players During Training Camp

    Frontiers in Nutrition, 2020, 7, 59

  • Use of plasma-free amino acids as biomarkers for detecting and predicting disease risk

    Nutrition Reviews, 2020, 78, 79-85

  • Simultaneous analysis of d, l-amino acids in human urine using a chirality-switchable biaryl axial tag and liquid chromatography electrospray ionization tandem mass spectrometry

    Symmetry, 2020, 12 (6), 913

  • Cdmo case study ajility: Streamlining drug product manufacturing

    Drug Development and Delivery, 2020, 20 (7), 34-37

  • Standardized ileal digestible lysine and valine-to-lysine requirements for optimal performance of 4 to 9-week-old Piétrain cross piglets

    Livestock Science, 2020, 241, 104263

  • The ideal protein profile for late-finishing pigs in precision feeding systems: Threonine

    Animal Feed Science and Technology, 2020, 265, 114500

  • Glutamate metabolism in a human intestinal epithelial cell layer model

    Amino Acids, 2020, 52 (November), 1505-1529

  • Evaluation of a Novel Boron-Containing α-D-Mannopyranoside for BNCT

    Cells, 2020, 9 (5), 1293

  • Genomic characterization of closely related species in the Rumoiensis clade infers ecogenomic signatures to non-marine environments

    Environmental Microbiology, 2020, 22 (8), 3205-3217

  • Forecasting disability-adjusted life years for chronic diseases: Reference and alternative scenarios of salt intake for 2017-2040 in Japan

    BMC Public Health, 2020, 20 (1), 1475

  • Bioavailability of rumen-protected methionine, lysine and histidine assessed by fecal amino acid excretion

    Animal Feed Science and Technology, 2020, 268, 114595

  • Crystal structure of a YeeE/YedE family protein engaged in thiosulfate uptake

    Science Advances, 2020, 6 (35), eaba7637

  • Stereospecific linalool production utilizing two-phase cultivation system in Pantoea ananatis

    Journal of Biotechnology, 2020, 324, 21-27

  • RESEARCH ARTICLE Translational Control of Muscle Mass Leucine-enriched amino acids maintain peripheral mTOR-Rheb localization independent of myofibrillar protein synthesis and mTORC1 signaling postexercise

    Journal of Applied Physiology, 2020, 129 (1), 133-143

  • Leucine-enriched essential amino acids improve recovery from post-exercise muscle damage independent of increases in integrated myofibrillar protein synthesis in young men

    Nutrients, 2020, 12 (4), 1061

  • Production of glutamate and stereospecific flavors, (S)-linalool and (+)-valencene, by Synechocystis sp. PCC6803

    Journal of Bioscience and Bioengineering, 2020, 130 (5), 464-470

  • Field testing an oil-based Trichoderma asperellum formulation for the biological control of cacao black pod disease, caused by Phytophthora megakarya

    Crop Protection, 2020, 132, 105134

  • Validation of preferred salt concentration in soup based on a randomized blinded experiment in multiple regions in Japan—influence of umami (l-glutamate) on saltiness and palatability of low-salt solutions

    Hypertension Research, 2020, 43 (6), 525-533

  • Metabolome-based discrimination analysis of shallot landraces and bulb onion cultivars associated with differences in the amino acid and flavonoid profiles

    Molecules, 2020, 25 (22), 5300

  • Universal Actuator for Efficient Silencing of Escherichia coli Genes Based on Convergent Transcription Resistant to Rho-Dependent Termination

    ACS Synthetic Biology, 2020, 9 (7), 1650-1664

  • Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media

    Scientific Reports, 2020, 10 (1), 17937

  • Quantification of the kokumi peptide, γ-glutamyl-valyl-glycine, in cheese: Comparison between cheese made from cow and ewe milk

    Journal of Dairy Science, 2020, 103 (9), 7801-7807

  • Application of Native Ion Exchange Mass Spectrometry to Intact and Subunit Analysis of Site-Specific Antibody-Drug Conjugates Produced by AJICAP First Generation Technology

    Journal of the American Society for Mass Spectrometry, 2020, 31 (8), 1706-1712

  • Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial

    Frontiers in Nutrition, 2020, 7, 586166

  • Data science-based modeling of the lysine fermentation process

    Journal of Bioscience and Bioengineering, 2020, 130 (4), 409-415

  • Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells

    Cell Chemical Biology, 2020, 27 (12), 1561-1570

  • Erratum to: Validation of preferred salt concentration in soup based on a randomized blinded experiment in multiple regions in Japan—influence of umami (l-glutamate) on saltiness and palatability of low-salt solutions (Hypertension Research, (2020), 43, 6, (525-533), 10.1038/s41440-020-0397-1)

    Hypertension Research, 2020, 43 (6), 579-581

  • Innovation in the food industry using microbial transglutaminase: Keys to success and future prospects

    Analytical Biochemistry, 2020, 597, 113638

  • Design, synthesis and evaluation of unnatural peptides as T1R2/T1R3 PAMs

    Bioorganic and Medicinal Chemistry Letters, 2020, 30 (8), 127000

  • A purification strategy utilizing hydrophobic interaction chromatography to obtain homogeneous species from a site-specific antibody drug conjugate produced by ajicaptm first generation

    Antibodies, 2020, 9 (2), 16

  • Valine requirement of female Cobb broilers from 8 to 21 days of age

    Journal of Applied Poultry Research, 2020, 29 (4), 775-785

  • Fermentative production of sulfur-containing amino acid with engineering putative L-cystathionine and L-cysteine uptake systems in Escherichia coli

    Journal of Bioscience and Bioengineering, 2020, 130 (1), 14-19

  • Plasma branched-chain and aromatic amino acids in relation to hypertension

    Nutrients, 2020, 12 (12), 3791, 1-11

  • Expression of feeding-related neuromodulatory signalling molecules in the mouse central olfactory system

    Scientific Reports, 2020, 10 (1), 890

  • Preoperative AminoIndex Cancer Screening (AICS) abnormalities predict postoperative recurrence in patients undergoing curative resection for non-small cell lung cancer

    BMC Cancer, 2020, 20 (1), 1100

  • Application of inorganic phosphate limitation to efficient isoprene production in Pantoea ananatis

    Journal of Applied Microbiology, 2020, 128 (3), 763-774

  • Proof of site-specificity of antibody-drug conjugates produced by chemical conjugation technology: AJICAP first generation

    Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2020, 1140, 121981

  • Open innovation platform using cloud-based applications and collaborative space: a case study of solubility prediction model development

    Chem-Bio Informatics Journal, 2020, 20, 5-18

  • AJICAP TM: Development of a chemical site-specific conjugation technology for antibody-drug conjugates

    Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 2020, 78 (5), 495-502

  • A novel one-step method for targeted multiplication of DNA fragments from the Escherichia coli chromosome mediated by coordinated functioning of λ and φ80 bacteriophage recombination systems

    Journal of Microbiological Methods, 2020, 170, 105842

  • Efficiency of standardized ileal digestible lysine utilization for whole body protein deposition in pregnant gilts and sows during early-, mid-, and late-gestation

    Journal of Animal Science, 2020, 98 (11), skaa340

  • Comprehensive dipeptide analysis by pre-column derivatization lc/ms/ms

    Bunseki Kagaku, 2020, 69 (4.5), 173-178

  • L-arginine supplementation during the final third of gestation improves litter uniformity and physical characteristics of neonatal piglet thermoregulation

    Journal of Animal Physiology and Animal Nutrition, 2020, 104 (2), 645-656

  • Effects of serial cervical or tail blood sampling on toxicity and toxicokinetic evaluation in rats

    Journal of Toxicological Sciences, 2020, 45 (10), 599-609

  • Development of an LC-NMR system using a diode array detector and a charged aerosol detector

    Bunseki Kagaku, 2020, 69 (3), 151-155

  • Effects on nitrogen balance and metabolism of branched-chain amino acids by growing pigs of supplementing isoleucine and valine to diets with adequate or excess concentrations of dietary leucine

    Journal of Animal Science, 2020, 98 (11), skaa346

  • Regulation of skeletal muscle function by amino acids

    Nutrients, 2020, 12 (1), 261

  • Detection and recognition thresholds for five basic tastes in patients with mild cognitive impairment and Alzheimer's disease dementia

    BMC Neurology, 2020, 20 (1), 110

  • Effects of capsinoids on daily physical activity, body composition and cold hypersensitivity in middle-aged and older adults: A randomized study

    Nutrients, 2020, 12 (1), 212

  • Intake and preference for dried bonito dashi in male Sprague-Dawley rats and C57BL/6 N mice

    Physiology and Behavior, 2020, 213, 112708

  • Protein Deficiency-Induced Behavioral Abnormalities and Neurotransmitter Loss in Aged Mice Are Ameliorated by Essential Amino Acids

    Frontiers in Nutrition, 2020, 7, 23

  • Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer

    Cancer Science, 2020, 111 (4), 1218-1227

  • Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity

    Journal of Obesity, 2020, 2020, 7154738

  • High-transparency adhesive-encapsulation film for OLED device

    Digest of Technical Papers - SID International Symposium, 2020, 51 (1), 1036-1039

  • Analytical comparison of antibody-drug conjugates based on good manufacturing practice strategies

    Analytical Sciences, 2020, 36 (7), 871-875

  • Awake functional MRI detects neural circuit dysfunction in a mouse model of autism

    Science Advances, 2020, 6 (6), eaav4520

  • Coacervation in cationic polyelectrolyte solutions with anionic amino acid surfactants

    Journal of Oleo Science, 2020, 69 (11), 1411-1416

  • Isolation of four xylanases capable of hydrolyzing corn fiber xylan from Paenibacillus sp. H2C

    Bioscience, Biotechnology and Biochemistry, 2020, 84 (3), 640-650

  • Lysine (protein) requirements of lactating sows

    Translational Animal Science, 2020, 4 (2), 750-763

  • Exogenous treatment with glutamate induces immune responses in Arabidopsis

    Molecular Plant-Microbe Interactions, 2020, 33 (3), 474-487

  • Lack of toxicological influences by microsampling (50 µlfrom jugular vein of rats in a collaborative 28-day study

    Journal of Toxicological Sciences, 2020, 45 (6), 319-325

  • Low-and no-calorie sweeteners (LNCS): Critical evaluation of their safety and health risks

    Food Science and Technology (Brazil), 2020, 40 (1), 1-10

  • Removal of volatile organic compounds in distillation steam by dbd decomposition treatment for water recycling in fermentation industry

    International Journal of Plasma Environmental Science and Technology, 2020, 14 (2), e02003, 1-8

  • Growth promotion in Corynebacterium glutamicum by overexpression of the NCgl2986 gene encoding a protein homologous to peptidoglycan amidases

    Journal of General and Applied Microbiology, 2020, 66 (1), 1-7

  • Expression and purification of the 5′-nucleotidase YitU from Bacillus species: its enzymatic properties and possible applications in biotechnology

    Applied Microbiology and Biotechnology, 2020, 104 (7), 2957-2972

  • Ultra-performance liquid chromatography (UPLC) for the determination of organic acids–The intermediates of branched-chain amino acid biosynthesis in Escherichia coli strains

    Journal of Liquid Chromatography and Related Technologies, 2020, 43 (19-20), 844-851

  • Development of amino acid focused metabolomics and its application

    Bunseki Kagaku, 2020, 69 (7.8), 329-339

  • Variation in lysine, threonine, and tryptophan availability in meat and bone meal as estimated by the slope-ratio growth assay technique in growing rats

    Animal Science Journal, 2020, 91 (1), e13413

  • Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model

    Science Advances, 2021, 7 (43), eabd5046

  • Fermentative production of enantiopure (S)-linalool using a metabolically engineered Pantoea ananatis

    Microbial Cell Factories, 2021, 20 (1) 54

  • Growth performance responses to increased tryptophan supplementation in growing barrows fed three different very low crude protein corn and soybean meal-based diets fortified with essential amino acids

    Animal Science Journal, 2021, 92 (1), e13605

  • Projections of disability-adjusted life years for major diseases due to a change in vegetable intake in 2017–2040 in Japan

    BMC Public Health, 2021, 21 (1), 770

  • Can umami taste be an adequate tool for reducing sodium in food preparations?

    International Journal of Food Science and Technology, 2021, 56 (10), 5315-5324

  • Amino acid-enriched plant-based RUTF treatment was not inferior to peanut-milk RUTF treatment in restoring plasma amino acid levels among patients with oedematous or non-oedematous malnutrition

    Scientific Reports, 2021, 11 (1), 12582

  • Determination of intracellular 2-hydroxyglutarate enantiomers using two-dimensional liquid chromatography

    Journal of Chromatography Open, 2021, 1, 100005

  • Increased carvone production in Escherichia coli by balancing limonene conversion enzyme expression via targeted quantification concatamer proteome analysis

    Scientific Reports, 2021, 11 (1), 22126

  • Microbial 5′-nucleotidases: their characteristics, roles in cellular metabolism, and possible practical applications

    Applied Microbiology and Biotechnology, 2021, 105 (20), 7661-7681

  • Recent Advances in Drug–Antibody Ratio Determination of Antibody–Drug Conjugates

    Chemical and Pharmaceutical Bulletin, 2021, 69 (10), 976-983

  • Lipoate-acid ligase a modification of native antibody: Synthesis and conjugation site analysis

    Bioorganic and Medicinal Chemistry Letters, 2021, 51, 128360

  • Association of plasma branched-chain and aromatic amino acids with reduction in kidney function evaluated in apparently healthy adults

    Journal of Clinical Medicine, 2021, 10 (22), 5234

  • Validation and standardization of DNA extraction and library construction methods for metagenomics-based human fecal microbiome measurements

    Microbiome, 2021, 9 (1), 95

  • An integrated computational pipeline for designing high-affinity nanobodies with expanded genetic codes

    Briefings in Bioinformatics, 2021, 22 (6), bbab338

  • Chemical Site-Specific Conjugation Platform to Improve the Pharmacokinetics and Therapeutic Index of Antibody-Drug Conjugates

    Molecular Pharmaceutics, 2021, 18 (11), 4058-4066

  • Comparing classical descriptive analysis with modified descriptive analysis, modified rate-all-that-apply, and modified check-all-that-apply

    Journal of Sensory Studies, 2021, 36 (5), e12684

  • Oral administration of cystine and theanine attenuates 5-fluorouracil-induced intestinal mucositis and diarrhea by suppressing both glutathione level decrease and ROS production in the small intestine of mucositis mouse model

    BMC Cancer, 2021, 21 (1), 1343

  • Identification of Core Cellulolytic Enzymes from the Talaromyces cellulolyticus Strains Y-94 and S6-25

    Applied Biochemistry and Microbiology, 2021, 57, S38-S45

  • Supplementing functional amino acids and polyphenols at low dose can restore performance and amino acid digestibility in broilers challenged with coccidiosis

    Livestock Science, 2021, 254, 104769

  • Chromatographic analysis of site-specific antibody-drug conjugates produced by AJICAP first-generation technology using a recombinant FcγIIIa receptor-ligand affinity column

    Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2021, 1177, 122753

  • Genetic controls of Tas1r3-independent sucrose consumption in mice

    Mammalian Genome, 2021, 32 (2), 70-93

  • At the Crossroads: Mechanisms of Apoptosis and Autophagy in Cell Life and Death

    Acta Naturae, 2021, 13 (2), 106-115

  • A chemical-specific adjustment factor for human interindividual differences in kinetics for glutamates (E620-625)

    Food and Chemical Toxicology, 2021, 147, 111910

  • One-step construction of ferritin encapsulation drugs for cancer chemotherapy

    Nanoscale, 2021, 13 (3), 1875-1883

  • The Association between Dietary Amino Acid Intake and Cognitive Decline 8 Years Later in Japanese Community-Dwelling Older Adults

    Journal of Nutrition, Health and Aging, 2021, 25 (2), 165-171

  • Glutamine and cystine-enriched diets modulate aquaporins gene expression in the small intestine of piglets

    PLoS ONE, 2021, 16 (1-Jan), e0245739

  • Effects of risedronate, alendronate, and minodronate alone or in combination with eldecalcitol on bone mineral density, quality, and strength in ovariectomized rats

    Bone Reports, 2021, 14, 101061

  • Incorporation of Halogenated Amino Acids into Antibody Fragments at Multiple Specific Sites Enhances Antigen Binding

    ChemBioChem, 2021, 22 (1), 120-123

  • Expansion of EasyClone-MarkerFree toolkit for Saccharomyces cerevisiae genome with new integration sites

    FEMS Yeast Research, 2021, 21 (4), foab027

  • Dietary supplementation with monosodium glutamate suppresses chemotherapy-induced downregulation of the t1r3 taste receptor subunit in head and neck cancer patients

    Nutrients, 2021, 13 (9), 2921

  • Induction of Fos expression in the rat brain after intragastric administration of dried bonito dashi

    Nutritional Neuroscience, 2021, 24 (9), 688-696

  • Dietary starch level and rumen-protected methionine, lysine, and histidine: Effects on milk yield, nitrogen, and energy utilization in dairy cows fed diets low in metabolizable protein

    Journal of Dairy Science, 2021, 104 (9), 9784-9800

  • A static model to analyze carbon and nitrogen partitioning in the mammary gland of lactating sows

    Animal, 2021, 15 (1), 100049

  • Development of dietary information literacy scale for competition (Dils-c) in japanese college athletes

    Journal of Nutritional Science and Vitaminology, 2021, 67 (1), 21-27

  • An overview of process development for antibody-drug conjugates produced by chemical conjugation technology

    Expert Opinion on Biological Therapy, 2021, 21 (7), 963-975

  • Effects of the L/N-Type Ca2+ channel blocker cilnidipine on the cardiac histological remodelling and inducibility of atrial fibrillation in high-salt-fed rats

    Biological and Pharmaceutical Bulletin, 2021, 44 (5), 707, 713

  • Powder coating and dissolution rate modification of L-leucine supplements with hydrophilic fumed SiO2 nanoparticles by ultrasonic irradiation in high-pressure liquid CO2

    Journal of Supercritical Fluids, 2021, 169, 105104

  • Determination of the optimum digestible isoleucine to lysine ratios for male Yield Plus × Ross 708 broilers between 1.0 and 4.0 kg body weight utilizing growth performance and carcass characteristics

    Poultry Science, 2021, 100 (9), 101307

  • Histidine dose-response effects on lactational performance and plasma amino acid concentrations in lactating dairy cows: 1. Metabolizable protein-adequate diet

    Journal of Dairy Science, 2021, 104 (9), 9902-9916

  • Stress condition on a restricted sodium diet using umami substance (L-glutamate) in a pilot randomized cross-over study

    Foods, 2021, 10 (8), 1739

  • Influence of dietary supplementation with an amino acid mixture on inflammatory markers, immune status and serum proteome in lps-challenged weaned piglets

    Animals, 2021, 11 (4), 1143

  • In-situ reverse phased hplc analysis of intact antibody-drug conjugates

    Analytical Sciences, 2021, 37 (8), 1171-1176

  • Cooperative Study Combining X-ray Crystal Structure Analysis and FMO Calculation: Interaction Analysis of FABP4 Inhibitors

    Recent Advances of the Fragment Molecular Orbital Method: Enhanced Performance and Applicability, 2021, 267-279

  • Cross-sectional association between the amino acid intake and episodic memory in middle- and old-aged community dwellers

    Japanese Journal of Geriatrics, 2021, 58 (4), 579-590

  • Lifecycle assessment of monosodium glutamate made from non-edible biomass

    Sustainability (Switzerland), 2021, 13 (7), 3951

  • A dynamic mammary gland model describing colostrum immunoglobulin transfer and milk production in lactating sows

    Journal of Animal Science, 2021, 99 (2), skab030

  • DEM simulation for optimal design of powder mixing in a ribbon mixer

    Advanced Powder Technology, 2021, 32 (5), 1735-1749

  • Prediction of disability-adjusted life years for diseases due to low fruit intake in 2017-2040 in Japan

    Public Health Nutrition, 2021, 24 (10), 3156-3166

  • Novel insulation materials suitable for FOWLP and FOPLP

    Proceedings - Electronic Components and Technology Conference, 2021, June, 729-735

  • Leucine-Enriched Essential Amino Acids Enhance the Antiseizure Effects of the Ketogenic Diet in Rats

    Frontiers in Neuroscience, 2021, 15, 637288

  • Efficient production of long double-stranded RNAs applicable to agricultural pest control by Corynebacterium glutamicum equipped with coliphage T7-expression system

    Applied Microbiology and Biotechnology, 2021, 105 (12), 4987-5000

  • Simple mercury determination using an enclosed quartz cell with cold vapour-atomic absorption spectrometry

    Analytical Methods, 2021, 13 (9), 1106-1109

  • Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates

    Exploration of Targeted Anti-tumor Therapy, 2021, 2 (6), 576-585

  • Changes of Plasma Amino Acid Profiles in Infants With a Nutrient-Fortified Complementary Food Supplement: Evidence From a 12-Month Single-Blind Cluster-Randomized Controlled Trial

    Frontiers in Nutrition, 2021, 8, 606002

  • The additive effects of exercise and essential amino acid on muscle mass and strength in community-dwelling older Japanese women with muscle mass decline, but not weakness and slowness: a randomized controlled and placebo trial

    Aging Clinical and Experimental Research, 2021, 33 (7), 1841-1852

  • Soft-sensor development for monitoring the lysine fermentation process

    Journal of Bioscience and Bioengineering, 2021, 132 (2), 183-189

  • l-Isoleucine (Ile) Promotes Anthocyanin Accumulation in Apples

    Journal of Plant Growth Regulation, 2021, 40 (2), 541-549

  • GPR120 agonists enhance the fatty orosensation when added to fat-containing system, but do not evoke it by themselves in humans

    Physiology and Behavior, 2021, 234, 113383

  • Histidine dose-response effects on lactational performance and plasma amino acid concentrations in lactating dairy cows: 2. Metabolizable protein-deficient diet

    Journal of Dairy Science, 2021, 104 (9), 9917-9930

  • Synthetic polymers as xeno-free materials for stabilizing basic fibroblast growth factor in human mesenchymal stem cell cultures

    Biochemistry and Biophysics Reports, 2021, 25, 100929

  • Genetics of mouse behavioral and peripheral neural responses to sucrose

    Mammalian Genome, 2021, 32 (2), 51-69

  • Production performance and plasma metabolite concentrations of broiler chickens fed low crude protein diets differing in Thr and Gly

    Animal Nutrition, 2021, 7 (2), 472-480

  • Leucine Dehydrogenase: Structure and Thermostability

    Subcellular Biochemistry, 2021, 96, 355-372

  • Human reconstructed kidney models

    In Vitro Cellular & Developmental Biology-Animal, 2021, 57 (2), 133-147

  • Cystine reduces tight junction permeability and intestinal inflammation induced by oxidative stress in Caco-2 cells

    Amino Acids, 2021, 53 (7), 1021-1032

  • Corrigendum to “Bioavailability of rumen-protected methionine, lysine and histidine assessed by fecal amino acid excretion” [Anim. Feed Sci. Technol. 268 (2020) 114595] (Animal Feed Science and Technology (2020) 268, (S0377840120304995), (10.1016/j.anifeedsci.2020.114595))

    Animal Feed Science and Technology, 2021, 274, 114747

  • Fine-scale vertical movements and behavior of immature skipjack tuna (katsuwonus pelamis) off eastern taiwan

    Journal of Marine Science and Technology (Taiwan), 2021, 29 (2), 207-219

  • Elucidation of the characteristics of soil sickness syndrome in japanese pear and construction of countermeasures using the rhizosphere soil assay method

    Agronomy, 2021, 11 (8), 1468

  • Association between the Prevalence of Frailty and Doubly Labeled Water-Calibrated Energy Intake among Community-Dwelling Older Adults

    Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 2021, 76 (5), 876-884

  • Structural changes in cell wall of Japanese radish accompanied by release of rhamnogalacturonan during pressure cooker heating

    Food Chemistry, 2021, 349, 129117

  • Effect of introducing a disulfide bridge on the thermostability of microbial transglutaminase from Streptomyces mobaraensis

    Applied Microbiology and Biotechnology, 2021, 105 (7), 2737-2745

  • A novel route for aspartame production by combining enzymatic and chemical reactions for industrial use

    Bioscience, Biotechnology and Biochemistry, 2021, 85 (2), 464-466

  • Tag-Free Enzymatic Modification for Antibody−Drug Conjugate Production

    ChemistrySelect, 2022, 7 (48), e202203753

  • Feeding rumen-protected lysine to dairy cows prepartum improves performance and health of their calves

    Journal of Dairy Science, 2022, 105 (3), 2256-2274

  • Ajinomoto Bio-Pharma Services: Giving You the Power to Make

    Drug Development and Delivery, 2022, 22 (8), 24-26

  • High-resolution structure of phosphoketolase from Bifidobacterium longum determined by cryo-EM single-particle analysis

    Journal of Structural Biology, 2022, 214 (2), 107842

  • Flavor encapsulation into chitosan-oleic acid complex particles and its controlled release characteristics during heating processes

    LWT, 2022, 167, 113815

  • Greater plasma essential amino acids and lower 3-methylhistidine with higher protein intake during endurance training: a randomised control trial

    Amino Acids, 2022

  • Effects of Non-Essential Amino Acids on Knee Joint Conditions in Adults: A Randomised, Double-Blind, Placebo-Controlled Trial

    Nutrients, 2022, 14 (17), 3628

  • Characterization and Demonstration of Mock Communities as Control Reagents for Accurate Human Microbiome Community Measurements

    Microbiology Spectrum, 2022, 10 (2), e01915

  • Detection of impurities in dietary supplements containing l-tryptophan

    Amino Acids, 2022, 54 (5), 835-839

  • Odorant metabolism of the olfactory cleft mucus in idiopathic olfactory impairment patients and healthy volunteers

    International Forum of Allergy and Rhinology, 2022, 12 (3), 293-301

  • The ins and outs of Bacillus proteases: Activities, functions and commercial significance

    FEMS Microbiology Reviews, 2022, 46 (1), fuab046

  • Simultaneous quantification of oligo-nucleic acids and a ferritin nanocage by size-exclusion chromatography hyphenated to inductively coupled plasma mass spectrometry for developing drug delivery systems

    Analytical Methods, 2022, 14 (22), 2219-2226

  • 3D Printing of Textured Soft Hybrid Meat Analogues

    Foods, 2022, 11 (3), 478

  • RNA Interference-Based Pesticides and Antiviral Agents: Microbial Overproduction Systems for Double-Stranded RNA for Applications in Agriculture and Aquaculture

    Applied Sciences (Switzerland), 2022, 12 (6), 2954

  • Scalable Syntheses and Biological Evaluation of Africane-Type Sesquiterpenoids

    Chemistry and Biodiversity, 2022, 19 (3), e202100890

  • Targeted Metabolome Profiling of Indonesian Shallots and Japanese Long-Day/Short-Day Bulb Onions

    Metabolites, 2022, 12 (12), 1260

  • Do Thiol Amino Acids Inhibit Threonine Deaminase Activity in E. coli? (Letter to the Editor)

    Current Microbiology, 2022, 79 (2), 42

  • Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model

    Journal for ImmunoTherapy of Cancer, 2022, 10 (5), e004420

  • Efficient enzymatic production of benzaldehyde from l-phenylalanine with a mutant form of 4-hydroxymandelate synthase

    Bioscience, Biotechnology and Biochemistry, 2022, 86 (12), 1718-1725

  • Effects of rumen-protected glutamate supplementation during the periparturient period on digestibility, inflammation, metabolic responses, and performance in dairy cows

    Journal of Dairy Science, 2022, 105 (4), 3129-3141

  • Efficient secretory production of proline/alanine/serine (PAS) biopolymers in Corynebacterium glutamicum yielding a monodisperse biological alternative to polyethylene glycol (PEG)

    Microbial Cell Factories, 2022, 21 (1), 227

  • Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment

    Frontiers in Nutrition, 2022, 9, 1040476

  • Identification and Quantitation of Taste-Active Compounds in Dried Scallops by Combined Application of the Sensomics and a Quantitative NMR Approach

    Journal of Agricultural and Food Chemistry, 2022, 70 (1), 247-259

  • Solution design to extend the pH range of the pH-responsive precipitation of a CspB fusion protein

    Protein Expression and Purification, 2022, 195-196, 106091

  • Effects of oral cystine and glutamine on exercise-induced changes in gastrointestinal permeability and damage markers in young men

    European Journal of Nutrition, 2022, 61 (5), 2331-2339

  • Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage

    npj Regenerative Medicine, 2022, 7 (1), 47

  • Effects of the potent GPR120 agonist, TUG-891, on sensory characteristics of whipped cream

    International Dairy Journal, 2022, 125, 105219

  • Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization

    Cell Reports, 2022, 40 (3), 111120

  • Characterizing Basal and Feed Media Effects on Mammalian Cell Cultures by Systems Engineering Approaches

    IFAC-PapersOnLine, 2022, 55 (7), 31-36

  • Data-driven and model-guided systematic framework for media development in CHO cell culture

    Metabolic Engineering, 2022, 73, 114-123

  • Nutrient Profiling of Japanese Dishes: The Development of a Novel Ajinomoto Group Nutrient Profiling System

    Frontiers in Nutrition, 2022, 9, 912148

  • A comparative study of swarm intelligence and artificial neural networks applications in modeling complex reaction processes

    Computer Aided Chemical Engineering, 2022, 51, 175-180

  • Effects of dietary leucine and tryptophan on serotonin metabolism and growth performance of growing pigs

    Journal of Animal Science, 2022, 100 (1), skab356

  • Corrigendum to “Lactational performance and plasma and muscle amino acid concentrations in dairy cows fed diets supplying 2 levels of digestible histidine and metabolizable protein” (J. Dairy Sci. 105:170–187) (Journal of Dairy Science (2022) 105(1) (170–187), (S0022030221009620), (10.3168/jds.2021-20800))

    Journal of Dairy Science, 2022, 105 (6), 5544

  • Analytical Chemistry of Impurities in Amino Acids Used as Nutrients: Recommendations for Regulatory Risk Management

    Nutrients, 2022, 14 (14), 2838

  • Erratum: Structural insights into the enhanced thermostability of cysteine substitution mutants of L-histidine decarboxylase from Photobacterium phosphoreum (J. Biochem. (2021) DOI: 10.1093/jb/mvab103)

    Journal of Biochemistry, 2022, 171 (5), 599

  • Sedimentation behavior of suspensions in milliflow reactors

    Chemical Engineering Science, 2022, 259, 117794

  • Development of Burden Scale for Dietary Behavior Appropriate for College Athletes

    Asian Journal of Sports Medicine, 2022, 13 (1), e114936

  • l-Tryptophan-starved cultivation enhances S-allyl-l-cysteine synthesis in various food-related microorganisms

    Bioscience, Biotechnology and Biochemistry, 2022, 86 (6), 792-799

  • Retronasal Aroma of Beef Pate Analyzed by a Chewing Simulator

    Molecules, 2022, 27 (10), 3259

  • Lipocalin 15 in the olfactory mucus is a biomarker for Bowman’s gland activity

    Scientific Reports, 2022, 12 (1), 9984

  • Structural insights into the enhanced thermostability of cysteine substitution mutants of L-histidine decarboxylase from Photobacterium phosphoreum

    Journal of Biochemistry, 2022, 171 (1), 31-40

  • Proposal for a nanocrystalline cellulose pilot plant integrated into a bleached pulp mill using ASPEN PLUS simulation; [PROPOSTA DE PLANTA PILOTO DE CELULOSE NANOCRISTALINA INTEGRADA A UMA FÁBRICA DE POLPA BRANQUEADA UTILIZANDO SIMULAÇÃO EM ASPEN PLUS]

    O Papel, 2022, 83 (7), 85-89

  • Biological Evaluation of Maytansinoid-Based Site-Specific Antibody-Drug Conjugate Produced by Fully Chemical Conjugation Approach: AJICAP®

    Frontiers in Bioscience - Landmark, 2022, 27 (8), 234

  • Practical Ferrioxalate Actinometry for the Determination of Photon Fluxes in Production-Oriented Photoflow Reactors

    Organic Process Research and Development, 2022, 26 (8), 2392-2402

  • Effect of feeding rumen-protected lysine through the transition period on postpartum uterine health of dairy cows

    Journal of Dairy Science, 2022, 105 (9), 7805-7819

  • Soup Consumption Inversely Correlates with the Risk of Obesity: A Systematic Review

    ACS Symposium Series, 2022, 1430, 13-21

  • Lactational performance and plasma and muscle amino acid concentrations in dairy cows fed diets supplying 2 levels of digestible histidine and metabolizable protein

    Journal of Dairy Science, 2022, 105 (1), 170-187

  • Adequate Protein Intake on Comprehensive Frailty in Older Adults: Kyoto-Kameoka Study

    Journal of Nutrition, Health and Aging, 2022, 26 (2), 161-168

  • Dietary risk factors of physical growth of Filipino school-aged children

    Food and Nutrition Research, 2022, 66, 7873

  • Dietary supplementation with branched-chain amino acids enhances milk production by lactating sows and the growth of suckling piglets

    Journal of Animal Science and Biotechnology, 2022, 13 (1), 65

  • Comparative Analysis of Catabolic and Anabolic Dehydroshikimate Dehydratases for 3,4-DHBA Production in Escherichia coli

    Microorganisms, 2022, 10 (7), 1357

  • “Nutrient-Repositioning”—Unexpected Amino Acid Functions—

    Journal of Nutritional Science and Vitaminology, 2022, 68, S134-S136

  • Current approaches for the purification of antibody–drug conjugates

    Journal of Separation Science, 2022, 45 (1), 27-37

  • Revealing a New Family of D-2-Hydroxyglutarate Dehydrogenases in Escherichia coli and Pantoea ananatis Encoded by ydiJ

    Microorganisms, 2022, 10 (9), 1766

  • Cystine reduces mitochondrial dysfunction in C2C12 myotubes under moderate oxidative stress induced by H2O2

    Amino Acids, 2022, 54 (8), 1203-1213

  • Genome engineering of the Corynebacterium glutamicum chromosome by the Extended Dual-In/Out strategy

    Journal of Microbiological Methods, 2022, 200, 106555

  • The Escherichia coli Amino Acid Uptake Protein CycA: Regulation of Its Synthesis and Practical Application in L-Isoleucine Production

    Microorganisms, 2022, 10 (3), 647

  • Establishment of in silico prediction methods for potential bitter molecules using the human T2R14 homology-model structure

    Chemical Biology Letters, 2022, 9 (3), 351

  • Environmental and Health-Related Lifecycle Impact Assessment of Reduced-Salt Meals in Japan

    Sustainability (Switzerland), 2022, 14 (14), 8265

  • Advanced Insulation Materials for Next Generation Packaging Technology

    2022 IEEE CPMT Symposium Japan, ICSJ 2022, 111-114

  • Identification of the Talaromyces cellulolyticus Gene Encoding an Extracellular Enzyme with β-galactosidase Activity and Testing it as a Reporter for Gene Expression Assays

    Molecular Biotechnology, 2022, 64 (6), 637-649

  • Cystine/Glutamine Mixture Supplementation Attenuated Fatigue during Endurance Exercise in Healthy Young Men by Enhancing Fatty Acid Utilization

    Sports, 2022, 10 (10), 147

  • Preferential freezing avoidance localised in anthers and embryo sacs in wintering Daphne kamtschatica var. jezoensis flower buds visualised by magnetic resonance imaging

    Plant Cell and Environment, 2022, 45 (7), 2109-2125

  • Microbial Production Potential of Pantoea ananatis: From Amino Acids to Secondary Metabolites

    Microorganisms, 2022, 10 (6), 1133

  • Dietary supplementation with monosodium glutamate enhances milk production by lactating sows and the growth of suckling piglets

    Amino Acids, 2022, 54 (7), 1055-1068

  • Cystine and theanine as stress-reducing amino acids—perioperative use for early recovery after surgical stress

    Nutrients, 2022, 14 (1), 129

  • Effects of an essential amino acid mixture on behavioral and psychological symptoms of dementia and executive function in patients with Alzheimer's disease: A double-blind, randomized, placebo-controlled exploratory clinical trial

    International Journal of Geriatric Psychiatry, 2022, 37 (9), GPS5782

  • Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics

    Communications Biology, 2022, 5 (1), 56

  • Development of a Novel Nutrition-Related Multivariate Biomarker for Mild Cognitive Impairment Based on the Plasma Free Amino Acid Profile

    Nutrients, 2022, 14 (3), 637

  • Hydrogel Formation by Glutamic-acid-based Organogelator Using Surfactant-mediated Gelation

    Journal of Oleo Science, 71 (8), 1169-1180

  • Engineering of Escherichia coli Glyceraldehyde-3-Phosphate Dehydrogenase with Dual NAD+/NADP+ Cofactor Specificity for Improving Amino Acid Production

    Microorganisms, 2022, 10 (5), 976

  • Xeno-Free Materials for Stabilizing Basic Fibroblast Growth Factor and Enhancing Cell Proliferation in Human Pluripotent Stem Cell Cultures

    Materials, 2022, 15 (10), 3687

  • The Properties and Application of Insulating Materials for High Performance IC Package

    Journal of Japan Institute of Electronics Packaging, 2022, 25 (3), 204-209

  • Effects of Five Amino Acids (Serine, Alanine, Glutamate, Aspartate, and Tyrosine) on Mental Health in Healthy Office Workers: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial

    Nutrients, 2022, 14 (11), 2357

  • Erratum to: Structural insights into the enhanced thermostability of cysteine substitution mutants of L-histidine decarboxylase from Photobacterium phosphoreum

    Journal of biochemistry, 2022, 171 (4), 471

  • Low Amino Acid Score of Breakfast is Associated with the Incidence of Cognitive Impairment in Older Japanese Adults: A Community-Based Longitudinal Study

    Journal of Prevention of Alzheimer's Disease, 2022, 9 (1), 151-157

  • Rational design of a disulfide bridge increases the thermostability of microbial transglutaminase

    Applied Microbiology and Biotechnology, 2022, 106 (12), 4553-4562

  • Three enzymes of Rhizobium radiobacter involved in the novel metabolism of two naturally occurring bioactive oxidative derivatives of l-isoleucine

    Bioscience, Biotechnology and Biochemistry, 2022, 86 (9), 1247-1254

  • Enzymatic Conjugation of Modified RNA Fragments by Ancestral RNA Ligase AncT4_2

    Applied and Environmental Microbiology, 2022, 88 (23)

  • Antibody-Drug Conjugate Synthesis Using Continuous Flow Microreactor Technology

    Organic Process Research and Development, 2022, 26 (9), 2766-2770

  • Effects of TUG-891, a potent GPR120 agonist, on the physical and oral lipid- coating properties, and secretion of saliva

    Physiology and Behavior, 2023, 265, 114160.

  • Plasma free amino acid profiles are associated with serum high molecular weight adiponectin levels in Japanese medical check-up population without type 2 diabetes mellitus

    Amino Acids, 2023, 55 (5), 639-649.

  • Tag-Free Antibody Modification Mediated by Lipoic Acid Ligase A: Application to Antibody-Drug Conjugates Production

    ChemistrySelect, 2023, 8 (9), e202204706.

  • Effect of Micellar Shape on Viscoelastic Behavior and Gel Network Structure of Hydrogel Formed by Surfactant-mediated Gelation Using Glutamic-acid-based Organogelator

    Journal of Oleo Science, 2023, 72 (6), 613-621.

  • Enhanced chondrogenic differentiation of iPS cell-derived mesenchymal stem/stromal cells via neural crest cell induction for hyaline cartilage repair

    Frontiers in Cell and Developmental Biology, 2023, 11, 1140717.

  • Physico-chemical and Textural Properties of 3D Printed Plant-based and Hybrid Soft Meat Analogs

    Plant Foods for Human Nutrition, 2023.

  • Salt intake reduction using umami substance-incorporated food: A secondary analysis of NHANES 2017-2018 data

    Public Health Nutrition, 2023, 26 (2), 488-495.

  • Evaluation of starch retrogradation by X-ray diffraction using a water-addition method

    LWT, 2023, 173, 114341.

  • Characterization of a xylanase belonging to the glycoside hydrolase family 5 subfamily 35 from Paenibacillus sp. H2C

    Bioscience, Biotechnology and Biochemistry, 2023, 87 (1), 54-62.

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    Physiology and Behavior, 2023, 261, 114084.

  • Efficient Microfluidic Screening Method Using a Fluorescent Immunosensor for Recombinant Protein Secretions

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    Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2023, 1215, 123588.

  • Screening of α-amino acid ester acyl transferase variant with improved activity by combining rational and random mutagenesis

    Journal of Biochemistry, 2023, 173 (1), 43-52.

  • The influence of serial 50 μL microsampling on rats administered azathioprine, the immunosuppressive drug

    Toxicology Reports, 2023, 10, 334-340.

  • Fatty acid overproduction by gut commensal microbiota exacerbates obesity

    Cell Metabolism, 2023, 35 (2), 361-375.

  • Combination of poly-γ-glutamic acid and galactooligosaccharide improves intestinal microbiota, defecation status, and relaxed mood in humans: a randomized, double-blind, parallel-group comparison trial

    Bioscience of Microbiota, Food and Health, 2023, 42 (1), 34-48.

  • Bacterially Secretable Single-Chain Tandem Macrocyclic Peptides for High Affinity and Inhibitory Activity

    ChemBioChem, 2023, 24 (2), e202200599.

  • Reducing salt intake with umami: A secondary analysis of data in the UK National Diet and Nutrition Survey

    Food Science and Nutrition, 2023, 11 (2), 872-882.

  • AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production

    Bioconjugate Chemistry, 2023.

  • Characteristic changes in plasma glutamate levels and free amino acid profiles in Japanese patients with type 1 diabetes mellitus

    Journal of Diabetes Investigation, 2023, 14 (1), 111-121.

  • School Lunch Programs and Nutritional Education Improve Knowledge, Attitudes, and Practices and Reduce the Prevalence of Anemia: A Pre-Post Intervention Study in an Indonesian Islamic Boarding School

    Nutrients, 2023, 15 (4), 1055.

  • Feeding rumen-protected lysine altered immune and metabolic biomarkers in dairy cows during the transition period

    Journal of Dairy Science, 2023, 106 (4), 2989-3007.

  • Effect of starch retrogradation on molecular dynamics of cooked rice by quasi-elastic neutron scattering

    Food Hydrocolloids, 2023, 141, 108728.

  • Ambient temperature structure of phosphoketolase from Bifidobacterium longum determined by serial femtosecond X-ray crystallography

    Acta Crystallographica Section D: Structural Biology, 2023, 79, Pt4, 290-303.

  • Modelling of salt intake reduction by incorporation of umami substances into Japanese foods: a cross-sectional study

    BMC Public Health, 2023, 23 (1), 516.

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    Biochemistry and Biophysics Reports, 2023, 33, 101435.

  • Acceleration of CRISPR/Cas9-Mediated Editing at Multiple Sites in the Saccharomyces cerevisiae Genome

    Methods and Protocols, 2023, 6 (2), 39.

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    Industrial Crops and Products, 2023, 193, 116175.

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    Journal of Toxicological Sciences, 2023, 48 (1).

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