For over 100 years since the discovery of umami substances, we have explored the possibilities of amino acids. We carry out R&D activities in a wide range of fields centered around "AminoScience," an approach developed through many years of research on amino acids. See below for a list of academic papers where our results have been published.
Association between soup consumption and obesity: A systematic review with meta-analysis
Physiology and Behavior, 2020, 225, 113103
Effects of capsinoid intake on brown adipose tissue vascular density and resting energy expenditure in healthy, middle‐aged adults: A randomized, double‐blind, placebo‐controlled study
Nutrients, 2020, 12 (9), 2676, 1-14
Synthesis and Biological Evaluation of Antibody Drug Conjugates Based on an Antibody Expression System: Conamax
ACS Omega, 2020, 5 (13), 7193-7200
Insight into Temperature Dependency and Design of Experiments towards Process Development for Cysteine-Based Antibody-Drug Conjugates
ChemistrySelect, 2020, 5 (28), 8435-8439
Characterization of newly developed pepper cultivars (Capsicum chinense) ‘Dieta0011-0301’, ‘Dieta0011-0602’, ‘Dieta0041-0401’, and ‘Dieta0041-0601’ containing high capsinoid concentrations and a strong fruity aroma
Bioscience, Biotechnology and Biochemistry, 2020, 84 (9), 1870-1885
Feeding rumen-protected lysine prepartum increases energy-corrected milk and milk component yields in Holstein cows during early lactation
Journal of Dairy Science, 2020, 103 (12), 11386-11400
L-serine and EPA relieve chronic low-back and knee pain in adults: A randomized, double-blind, placebo-controlled trial
Journal of Nutrition, 2020, 150 (9), 2278-2286
Structure–Activity Relationship Study of T1R2/T1R3 Positive Allosteric Modulators and Evaluation of Their Enhancing Effect on Various Sweeteners
ChemistrySelect, 2020, 5 (30), 9457-9460
The effect of leucine-enriched essential amino acid supplementation on anabolic and catabolic signaling in human skeletal muscle after acute resistance exercise: A randomized, double-blind, placebo-controlled, parallel-group comparison trial
Nutrients, 2020, 12 (8), 2421, 1-15
Characterization of the Corynebacterium glutamicum dehydroshikimate dehydratase QsuB and its potential for microbial production of protocatechuic acid
PLoS ONE, 2020, 15 (8 August), e0231560
Histidine: A systematic review on metabolism and physiological effects in human and different animal species
Nutrients, 2020, 12 (5), 1414
Dispensable amino acids, except glutamine and proline, are ideal nitrogen sources for protein synthesis in the presence of adequate indispensable amino acids in adult men
Journal of Nutrition, 2020, 150 (9), 2398-2404
Nitrogen Balance in Female Japanese National Handball Players During Training Camp
Frontiers in Nutrition, 2020, 7, 59
Use of plasma-free amino acids as biomarkers for detecting and predicting disease risk
Nutrition Reviews, 2020, 78, 79-85
Simultaneous analysis of d, l-amino acids in human urine using a chirality-switchable biaryl axial tag and liquid chromatography electrospray ionization tandem mass spectrometry
Symmetry, 2020, 12 (6), 913
Cdmo case study ajility: Streamlining drug product manufacturing
Drug Development and Delivery, 2020, 20 (7), 34-37
Standardized ileal digestible lysine and valine-to-lysine requirements for optimal performance of 4 to 9-week-old Piétrain cross piglets
Livestock Science, 2020, 241, 104263
The ideal protein profile for late-finishing pigs in precision feeding systems: Threonine
Animal Feed Science and Technology, 2020, 265, 114500
Glutamate metabolism in a human intestinal epithelial cell layer model
Amino Acids, 2020, 52 (November), 1505-1529
Evaluation of a Novel Boron-Containing α-D-Mannopyranoside for BNCT
Cells, 2020, 9 (5), 1293
Genomic characterization of closely related species in the Rumoiensis clade infers ecogenomic signatures to non-marine environments
Forecasting disability-adjusted life years for chronic diseases: Reference and alternative scenarios of salt intake for 2017-2040 in Japan
BMC Public Health, 2020, 20 (1), 1475
Bioavailability of rumen-protected methionine, lysine and histidine assessed by fecal amino acid excretion
Animal Feed Science and Technology, 2020, 268, 114595
Crystal structure of a YeeE/YedE family protein engaged in thiosulfate uptake
Science Advances, 2020, 6 (35), eaba7637
Stereospecific linalool production utilizing two-phase cultivation system in Pantoea ananatis
Journal of Biotechnology, 2020, 324, 21-27
RESEARCH ARTICLE Translational Control of Muscle Mass Leucine-enriched amino acids maintain peripheral mTOR-Rheb localization independent of myofibrillar protein synthesis and mTORC1 signaling postexercise
Journal of Applied Physiology, 2020, 129 (1), 133-143
Leucine-enriched essential amino acids improve recovery from post-exercise muscle damage independent of increases in integrated myofibrillar protein synthesis in young men
Nutrients, 2020, 12 (4), 1061
Production of glutamate and stereospecific flavors, (S)-linalool and (+)-valencene, by Synechocystis sp. PCC6803
Journal of Bioscience and Bioengineering, 2020, 130 (5), 464-470
Field testing an oil-based Trichoderma asperellum formulation for the biological control of cacao black pod disease, caused by Phytophthora megakarya
Crop Protection, 2020, 132, 105134
Validation of preferred salt concentration in soup based on a randomized blinded experiment in multiple regions in Japan—influence of umami (l-glutamate) on saltiness and palatability of low-salt solutions
Hypertension Research, 2020, 43 (6), 525-533
Metabolome-based discrimination analysis of shallot landraces and bulb onion cultivars associated with differences in the amino acid and flavonoid profiles
Molecules, 2020, 25 (22), 5300
Universal Actuator for Efficient Silencing of Escherichia coli Genes Based on Convergent Transcription Resistant to Rho-Dependent Termination
ACS Synthetic Biology, 2020, 9 (7), 1650-1664
Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media
Scientific Reports, 2020, 10 (1), 17937
Quantification of the kokumi peptide, γ-glutamyl-valyl-glycine, in cheese: Comparison between cheese made from cow and ewe milk
Journal of Dairy Science, 2020, 103 (9), 7801-7807
Application of Native Ion Exchange Mass Spectrometry to Intact and Subunit Analysis of Site-Specific Antibody-Drug Conjugates Produced by AJICAP First Generation Technology
Journal of the American Society for Mass Spectrometry, 2020, 31 (8), 1706-1712
Intake of Seven Essential Amino Acids Improves Cognitive Function and Psychological and Social Function in Middle-Aged and Older Adults: A Double-Blind, Randomized, Placebo-Controlled Trial
Frontiers in Nutrition, 2020, 7, 586166
Data science-based modeling of the lysine fermentation process
Journal of Bioscience and Bioengineering, 2020, 130 (4), 409-415
Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells
Cell Chemical Biology, 2020, 27 (12), 1561-1570
Erratum to: Validation of preferred salt concentration in soup based on a randomized blinded experiment in multiple regions in Japan—influence of umami (l-glutamate) on saltiness and palatability of low-salt solutions (Hypertension Research, (2020), 43, 6, (525-533), 10.1038/s41440-020-0397-1)
Hypertension Research, 2020, 43 (6), 579-581
Innovation in the food industry using microbial transglutaminase: Keys to success and future prospects
Analytical Biochemistry, 2020, 597, 113638
Design, synthesis and evaluation of unnatural peptides as T1R2/T1R3 PAMs
Bioorganic and Medicinal Chemistry Letters, 2020, 30 (8), 127000
A purification strategy utilizing hydrophobic interaction chromatography to obtain homogeneous species from a site-specific antibody drug conjugate produced by ajicaptm first generation
Antibodies, 2020, 9 (2), 16
Valine requirement of female Cobb broilers from 8 to 21 days of age
Journal of Applied Poultry Research, 2020, 29 (4), 775-785
Fermentative production of sulfur-containing amino acid with engineering putative L-cystathionine and L-cysteine uptake systems in Escherichia coli
Journal of Bioscience and Bioengineering, 2020, 130 (1), 14-19
Plasma branched-chain and aromatic amino acids in relation to hypertension
Nutrients, 2020, 12 (12), 3791, 1-11
Expression of feeding-related neuromodulatory signalling molecules in the mouse central olfactory system
Scientific Reports, 2020, 10 (1), 890
Preoperative AminoIndex Cancer Screening (AICS) abnormalities predict postoperative recurrence in patients undergoing curative resection for non-small cell lung cancer
BMC Cancer, 2020, 20 (1), 1100
Application of inorganic phosphate limitation to efficient isoprene production in Pantoea ananatis
Journal of Applied Microbiology, 2020, 128 (3), 763-774
Proof of site-specificity of antibody-drug conjugates produced by chemical conjugation technology: AJICAP first generation
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2020, 1140, 121981
Open innovation platform using cloud-based applications and collaborative space: a case study of solubility prediction model development
Chem-Bio Informatics Journal, 2020, 20, 5-18
AJICAP TM: Development of a chemical site-specific conjugation technology for antibody-drug conjugates
A novel one-step method for targeted multiplication of DNA fragments from the Escherichia coli chromosome mediated by coordinated functioning of λ and φ80 bacteriophage recombination systems
Journal of Microbiological Methods, 2020, 170, 105842
Efficiency of standardized ileal digestible lysine utilization for whole body protein deposition in pregnant gilts and sows during early-, mid-, and late-gestation
Journal of Animal Science, 2020, 98 (11), skaa340
Comprehensive dipeptide analysis by pre-column derivatization lc/ms/ms
Bunseki Kagaku, 2020, 69 (4.5), 173-178
L-arginine supplementation during the final third of gestation improves litter uniformity and physical characteristics of neonatal piglet thermoregulation
Journal of Animal Physiology and Animal Nutrition, 2020, 104 (2), 645-656
Effects of serial cervical or tail blood sampling on toxicity and toxicokinetic evaluation in rats
Journal of Toxicological Sciences, 2020, 45 (10), 599-609
Development of an LC-NMR system using a diode array detector and a charged aerosol detector
Bunseki Kagaku, 2020, 69 (3), 151-155
Effects on nitrogen balance and metabolism of branched-chain amino acids by growing pigs of supplementing isoleucine and valine to diets with adequate or excess concentrations of dietary leucine
Journal of Animal Science, 2020, 98 (11), skaa346
Regulation of skeletal muscle function by amino acids
Nutrients, 2020, 12 (1), 261
Detection and recognition thresholds for five basic tastes in patients with mild cognitive impairment and Alzheimer's disease dementia
BMC Neurology, 2020, 20 (1), 110
Effects of capsinoids on daily physical activity, body composition and cold hypersensitivity in middle-aged and older adults: A randomized study
Nutrients, 2020, 12 (1), 212
Intake and preference for dried bonito dashi in male Sprague-Dawley rats and C57BL/6 N mice
Physiology and Behavior, 2020, 213, 112708
Protein Deficiency-Induced Behavioral Abnormalities and Neurotransmitter Loss in Aged Mice Are Ameliorated by Essential Amino Acids
Frontiers in Nutrition, 2020, 7, 23
Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer
Cancer Science, 2020, 111 (4), 1218-1227
Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity
Journal of Obesity, 2020, 2020, 7154738
High-transparency adhesive-encapsulation film for OLED device
Digest of Technical Papers - SID International Symposium, 2020, 51 (1), 1036-1039
Analytical comparison of antibody-drug conjugates based on good manufacturing practice strategies
Analytical Sciences, 2020, 36 (7), 871-875
Awake functional MRI detects neural circuit dysfunction in a mouse model of autism
Science Advances, 2020, 6 (6), eaav4520
Coacervation in cationic polyelectrolyte solutions with anionic amino acid surfactants
Journal of Oleo Science, 2020, 69 (11), 1411-1416
Isolation of four xylanases capable of hydrolyzing corn fiber xylan from Paenibacillus sp. H2C
Bioscience, Biotechnology and Biochemistry, 2020, 84 (3), 640-650
Lack of toxicological influences by microsampling (50 µlfrom jugular vein of rats in a collaborative 28-day study
Journal of Toxicological Sciences, 2020, 45 (6), 319-325
Low-and no-calorie sweeteners (LNCS): Critical evaluation of their safety and health risks
Food Science and Technology (Brazil), 2020, 40 (1), 1-10
Removal of volatile organic compounds in distillation steam by dbd decomposition treatment for water recycling in fermentation industry
International Journal of Plasma Environmental Science and Technology, 2020, 14 (2), e02003, 1-8
Growth promotion in Corynebacterium glutamicum by overexpression of the NCgl2986 gene encoding a protein homologous to peptidoglycan amidases
Journal of General and Applied Microbiology, 2020, 66 (1), 1-7
Expression and purification of the 5′-nucleotidase YitU from Bacillus species: its enzymatic properties and possible applications in biotechnology
Applied Microbiology and Biotechnology, 2020, 104 (7), 2957-2972
Ultra-performance liquid chromatography (UPLC) for the determination of organic acids–The intermediates of branched-chain amino acid biosynthesis in Escherichia coli strains
Journal of Liquid Chromatography and Related Technologies, 2020, 43 (19-20), 844-851
Development of amino acid focused metabolomics and its application
Bunseki Kagaku, 2020, 69 (7.8), 329-339
Variation in lysine, threonine, and tryptophan availability in meat and bone meal as estimated by the slope-ratio growth assay technique in growing rats
Animal Science Journal, 2020, 91 (1), e13413
Neurodegenerative processes accelerated by protein malnutrition and decelerated by essential amino acids in a tauopathy mouse model
Science Advances, 2021, 7 (43), eabd5046
Fermentative production of enantiopure (S)-linalool using a metabolically engineered Pantoea ananatis
Microbial Cell Factories, 2021, 20 (1) 54
Growth performance responses to increased tryptophan supplementation in growing barrows fed three different very low crude protein corn and soybean meal-based diets fortified with essential amino acids
Animal Science Journal, 2021, 92 (1), e13605
Projections of disability-adjusted life years for major diseases due to a change in vegetable intake in 2017–2040 in Japan
BMC Public Health, 2021, 21 (1), 770
Can umami taste be an adequate tool for reducing sodium in food preparations?
International Journal of Food Science and Technology, 2021, 56 (10), 5315-5324
Amino acid-enriched plant-based RUTF treatment was not inferior to peanut-milk RUTF treatment in restoring plasma amino acid levels among patients with oedematous or non-oedematous malnutrition
Scientific Reports, 2021, 11 (1), 12582
Determination of intracellular 2-hydroxyglutarate enantiomers using two-dimensional liquid chromatography
Journal of Chromatography Open, 2021, 1, 100005
Increased carvone production in Escherichia coli by balancing limonene conversion enzyme expression via targeted quantification concatamer proteome analysis
Scientific Reports, 2021, 11 (1), 22126
Microbial 5′-nucleotidases: their characteristics, roles in cellular metabolism, and possible practical applications
Applied Microbiology and Biotechnology, 2021, 105 (20), 7661-7681
Recent Advances in Drug–Antibody Ratio Determination of Antibody–Drug Conjugates
Chemical and Pharmaceutical Bulletin, 2021, 69 (10), 976-983
Lipoate-acid ligase a modification of native antibody: Synthesis and conjugation site analysis
Bioorganic and Medicinal Chemistry Letters, 2021, 51, 128360
Association of plasma branched-chain and aromatic amino acids with reduction in kidney function evaluated in apparently healthy adults
Journal of Clinical Medicine, 2021, 10 (22), 5234
Validation and standardization of DNA extraction and library construction methods for metagenomics-based human fecal microbiome measurements
Microbiome, 2021, 9 (1), 95
An integrated computational pipeline for designing high-affinity nanobodies with expanded genetic codes
Briefings in Bioinformatics, 2021, 22 (6), bbab338
Chemical Site-Specific Conjugation Platform to Improve the Pharmacokinetics and Therapeutic Index of Antibody-Drug Conjugates
Molecular Pharmaceutics, 2021, 18 (11), 4058-4066
Comparing classical descriptive analysis with modified descriptive analysis, modified rate-all-that-apply, and modified check-all-that-apply
Journal of Sensory Studies, 2021, 36 (5), e12684
Oral administration of cystine and theanine attenuates 5-fluorouracil-induced intestinal mucositis and diarrhea by suppressing both glutathione level decrease and ROS production in the small intestine of mucositis mouse model
BMC Cancer, 2021, 21 (1), 1343
Identification of Core Cellulolytic Enzymes from the Talaromyces cellulolyticus Strains Y-94 and S6-25
Applied Biochemistry and Microbiology, 2021, 57, S38-S45
Supplementing functional amino acids and polyphenols at low dose can restore performance and amino acid digestibility in broilers challenged with coccidiosis
Livestock Science, 2021, 254, 104769
Chromatographic analysis of site-specific antibody-drug conjugates produced by AJICAP first-generation technology using a recombinant FcγIIIa receptor-ligand affinity column
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2021, 1177, 122753
Genetic controls of Tas1r3-independent sucrose consumption in mice
Mammalian Genome, 2021, 32 (2), 70-93
At the Crossroads: Mechanisms of Apoptosis and Autophagy in Cell Life and Death
Acta Naturae, 2021, 13 (2), 106-115
A chemical-specific adjustment factor for human interindividual differences in kinetics for glutamates (E620-625)
Food and Chemical Toxicology, 2021, 147, 111910
One-step construction of ferritin encapsulation drugs for cancer chemotherapy
Nanoscale, 2021, 13 (3), 1875-1883
The Association between Dietary Amino Acid Intake and Cognitive Decline 8 Years Later in Japanese Community-Dwelling Older Adults
Journal of Nutrition, Health and Aging, 2021, 25 (2), 165-171
Glutamine and cystine-enriched diets modulate aquaporins gene expression in the small intestine of piglets
PLoS ONE, 2021, 16 (1-Jan), e0245739
Effects of risedronate, alendronate, and minodronate alone or in combination with eldecalcitol on bone mineral density, quality, and strength in ovariectomized rats
Bone Reports, 2021, 14, 101061
Incorporation of Halogenated Amino Acids into Antibody Fragments at Multiple Specific Sites Enhances Antigen Binding
ChemBioChem, 2021, 22 (1), 120-123
Expansion of EasyClone-MarkerFree toolkit for Saccharomyces cerevisiae genome with new integration sites
FEMS Yeast Research, 2021, 21 (4), foab027
Dietary supplementation with monosodium glutamate suppresses chemotherapy-induced downregulation of the t1r3 taste receptor subunit in head and neck cancer patients
Nutrients, 2021, 13 (9), 2921
Induction of Fos expression in the rat brain after intragastric administration of dried bonito dashi
Nutritional Neuroscience, 2021, 24 (9), 688-696
Dietary starch level and rumen-protected methionine, lysine, and histidine: Effects on milk yield, nitrogen, and energy utilization in dairy cows fed diets low in metabolizable protein
Journal of Dairy Science, 2021, 104 (9), 9784-9800
A static model to analyze carbon and nitrogen partitioning in the mammary gland of lactating sows
Animal, 2021, 15 (1), 100049
Development of dietary information literacy scale for competition (Dils-c) in japanese college athletes
Journal of Nutritional Science and Vitaminology, 2021, 67 (1), 21-27
An overview of process development for antibody-drug conjugates produced by chemical conjugation technology
Expert Opinion on Biological Therapy, 2021, 21 (7), 963-975
Effects of the L/N-Type Ca2+ channel blocker cilnidipine on the cardiac histological remodelling and inducibility of atrial fibrillation in high-salt-fed rats
Biological and Pharmaceutical Bulletin, 2021, 44 (5), 707, 713
Powder coating and dissolution rate modification of L-leucine supplements with hydrophilic fumed SiO2 nanoparticles by ultrasonic irradiation in high-pressure liquid CO2
Journal of Supercritical Fluids, 2021, 169, 105104
Determination of the optimum digestible isoleucine to lysine ratios for male Yield Plus × Ross 708 broilers between 1.0 and 4.0 kg body weight utilizing growth performance and carcass characteristics
Poultry Science, 2021, 100 (9), 101307
Histidine dose-response effects on lactational performance and plasma amino acid concentrations in lactating dairy cows: 1. Metabolizable protein-adequate diet
Journal of Dairy Science, 2021, 104 (9), 9902-9916
Stress condition on a restricted sodium diet using umami substance (L-glutamate) in a pilot randomized cross-over study
Foods, 2021, 10 (8), 1739
Influence of dietary supplementation with an amino acid mixture on inflammatory markers, immune status and serum proteome in lps-challenged weaned piglets
Animals, 2021, 11 (4), 1143
In-situ reverse phased hplc analysis of intact antibody-drug conjugates
Analytical Sciences, 2021, 37 (8), 1171-1176
Cooperative Study Combining X-ray Crystal Structure Analysis and FMO Calculation: Interaction Analysis of FABP4 Inhibitors
Recent Advances of the Fragment Molecular Orbital Method: Enhanced Performance and Applicability, 2021, 267-279
Cross-sectional association between the amino acid intake and episodic memory in middle- and old-aged community dwellers
Japanese Journal of Geriatrics, 2021, 58 (4), 579-590
Lifecycle assessment of monosodium glutamate made from non-edible biomass
Sustainability (Switzerland), 2021, 13 (7), 3951
A dynamic mammary gland model describing colostrum immunoglobulin transfer and milk production in lactating sows
Journal of Animal Science, 2021, 99 (2), skab030
DEM simulation for optimal design of powder mixing in a ribbon mixer
Prediction of disability-adjusted life years for diseases due to low fruit intake in 2017-2040 in Japan
Public Health Nutrition, 2021, 24 (10), 3156-3166
Novel insulation materials suitable for FOWLP and FOPLP
Proceedings - Electronic Components and Technology Conference, 2021, June, 729-735
Leucine-Enriched Essential Amino Acids Enhance the Antiseizure Effects of the Ketogenic Diet in Rats
Frontiers in Neuroscience, 2021, 15, 637288
Efficient production of long double-stranded RNAs applicable to agricultural pest control by Corynebacterium glutamicum equipped with coliphage T7-expression system
Applied Microbiology and Biotechnology, 2021, 105 (12), 4987-5000
Simple mercury determination using an enclosed quartz cell with cold vapour-atomic absorption spectrometry
Analytical Methods, 2021, 13 (9), 1106-1109
Physical characteristics comparison between maytansinoid-based and auristatin-based antibody-drug conjugates
Exploration of Targeted Anti-tumor Therapy, 2021, 2 (6), 576-585
Changes of Plasma Amino Acid Profiles in Infants With a Nutrient-Fortified Complementary Food Supplement: Evidence From a 12-Month Single-Blind Cluster-Randomized Controlled Trial
Frontiers in Nutrition, 2021, 8, 606002
The additive effects of exercise and essential amino acid on muscle mass and strength in community-dwelling older Japanese women with muscle mass decline, but not weakness and slowness: a randomized controlled and placebo trial
Aging Clinical and Experimental Research, 2021, 33 (7), 1841-1852
Soft-sensor development for monitoring the lysine fermentation process
Journal of Bioscience and Bioengineering, 2021, 132 (2), 183-189
l-Isoleucine (Ile) Promotes Anthocyanin Accumulation in Apples
Journal of Plant Growth Regulation, 2021, 40 (2), 541-549
GPR120 agonists enhance the fatty orosensation when added to fat-containing system, but do not evoke it by themselves in humans
Physiology and Behavior, 2021, 234, 113383
Histidine dose-response effects on lactational performance and plasma amino acid concentrations in lactating dairy cows: 2. Metabolizable protein-deficient diet
Journal of Dairy Science, 2021, 104 (9), 9917-9930
Synthetic polymers as xeno-free materials for stabilizing basic fibroblast growth factor in human mesenchymal stem cell cultures
Biochemistry and Biophysics Reports, 2021, 25, 100929
Genetics of mouse behavioral and peripheral neural responses to sucrose
Mammalian Genome, 2021, 32 (2), 51-69
Production performance and plasma metabolite concentrations of broiler chickens fed low crude protein diets differing in Thr and Gly
Animal Nutrition, 2021, 7 (2), 472-480
Leucine Dehydrogenase: Structure and Thermostability
Subcellular Biochemistry, 2021, 96, 355-372
Human reconstructed kidney models
In Vitro Cellular & Developmental Biology-Animal, 2021, 57 (2), 133-147
Cystine reduces tight junction permeability and intestinal inflammation induced by oxidative stress in Caco-2 cells
Amino Acids, 2021, 53 (7), 1021-1032
Corrigendum to “Bioavailability of rumen-protected methionine, lysine and histidine assessed by fecal amino acid excretion” [Anim. Feed Sci. Technol. 268 (2020) 114595] (Animal Feed Science and Technology (2020) 268, (S0377840120304995), (10.1016/j.anifeedsci.2020.114595))
Animal Feed Science and Technology, 2021, 274, 114747
Fine-scale vertical movements and behavior of immature skipjack tuna (katsuwonus pelamis) off eastern taiwan
Journal of Marine Science and Technology (Taiwan), 2021, 29 (2), 207-219
Elucidation of the characteristics of soil sickness syndrome in japanese pear and construction of countermeasures using the rhizosphere soil assay method
Agronomy, 2021, 11 (8), 1468
Association between the Prevalence of Frailty and Doubly Labeled Water-Calibrated Energy Intake among Community-Dwelling Older Adults
Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 2021, 76 (5), 876-884
Structural changes in cell wall of Japanese radish accompanied by release of rhamnogalacturonan during pressure cooker heating
Food Chemistry, 2021, 349, 129117
Effect of introducing a disulfide bridge on the thermostability of microbial transglutaminase from Streptomyces mobaraensis
Applied Microbiology and Biotechnology, 2021, 105 (7), 2737-2745
A novel route for aspartame production by combining enzymatic and chemical reactions for industrial use
Bioscience, Biotechnology and Biochemistry, 2021, 85 (2), 464-466
Tag-Free Enzymatic Modification for Antibody−Drug Conjugate Production
ChemistrySelect, 2022, 7 (48), e202203753
Feeding rumen-protected lysine to dairy cows prepartum improves performance and health of their calves
Journal of Dairy Science, 2022, 105 (3), 2256-2274
Ajinomoto Bio-Pharma Services: Giving You the Power to Make
Drug Development and Delivery, 2022, 22 (8), 24-26
High-resolution structure of phosphoketolase from Bifidobacterium longum determined by cryo-EM single-particle analysis
Journal of Structural Biology, 2022, 214 (2), 107842
Flavor encapsulation into chitosan-oleic acid complex particles and its controlled release characteristics during heating processes
LWT, 2022, 167, 113815
Greater plasma essential amino acids and lower 3-methylhistidine with higher protein intake during endurance training: a randomised control trial
Amino Acids, 2022
Effects of Non-Essential Amino Acids on Knee Joint Conditions in Adults: A Randomised, Double-Blind, Placebo-Controlled Trial
Nutrients, 2022, 14 (17), 3628
Characterization and Demonstration of Mock Communities as Control Reagents for Accurate Human Microbiome Community Measurements
Microbiology Spectrum, 2022, 10 (2), e01915
Detection of impurities in dietary supplements containing l-tryptophan
Amino Acids, 2022, 54 (5), 835-839
Odorant metabolism of the olfactory cleft mucus in idiopathic olfactory impairment patients and healthy volunteers
International Forum of Allergy and Rhinology, 2022, 12 (3), 293-301
The ins and outs of Bacillus proteases: Activities, functions and commercial significance
FEMS Microbiology Reviews, 2022, 46 (1), fuab046
Simultaneous quantification of oligo-nucleic acids and a ferritin nanocage by size-exclusion chromatography hyphenated to inductively coupled plasma mass spectrometry for developing drug delivery systems
Analytical Methods, 2022, 14 (22), 2219-2226
3D Printing of Textured Soft Hybrid Meat Analogues
Foods, 2022, 11 (3), 478
RNA Interference-Based Pesticides and Antiviral Agents: Microbial Overproduction Systems for Double-Stranded RNA for Applications in Agriculture and Aquaculture
Scalable Syntheses and Biological Evaluation of Africane-Type Sesquiterpenoids
Chemistry and Biodiversity, 2022, 19 (3), e202100890
Targeted Metabolome Profiling of Indonesian Shallots and Japanese Long-Day/Short-Day Bulb Onions
Metabolites, 2022, 12 (12), 1260
Do Thiol Amino Acids Inhibit Threonine Deaminase Activity in E. coli? (Letter to the Editor)
Current Microbiology, 2022, 79 (2), 42
Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model
Journal for ImmunoTherapy of Cancer, 2022, 10 (5), e004420
Efficient enzymatic production of benzaldehyde from l-phenylalanine with a mutant form of 4-hydroxymandelate synthase
Bioscience, Biotechnology and Biochemistry, 2022, 86 (12), 1718-1725
Effects of rumen-protected glutamate supplementation during the periparturient period on digestibility, inflammation, metabolic responses, and performance in dairy cows
Journal of Dairy Science, 2022, 105 (4), 3129-3141
Efficient secretory production of proline/alanine/serine (PAS) biopolymers in Corynebacterium glutamicum yielding a monodisperse biological alternative to polyethylene glycol (PEG)
Microbial Cell Factories, 2022, 21 (1), 227
Decreased circulating branched-chain amino acids are associated with development of Alzheimer’s disease in elderly individuals with mild cognitive impairment
Frontiers in Nutrition, 2022, 9, 1040476
Identification and Quantitation of Taste-Active Compounds in Dried Scallops by Combined Application of the Sensomics and a Quantitative NMR Approach
Journal of Agricultural and Food Chemistry, 2022, 70 (1), 247-259
Solution design to extend the pH range of the pH-responsive precipitation of a CspB fusion protein
Protein Expression and Purification, 2022, 195-196, 106091
Effects of oral cystine and glutamine on exercise-induced changes in gastrointestinal permeability and damage markers in young men
European Journal of Nutrition, 2022, 61 (5), 2331-2339
Induction of functional xeno-free MSCs from human iPSCs via a neural crest cell lineage
npj Regenerative Medicine, 2022, 7 (1), 47
Effects of the potent GPR120 agonist, TUG-891, on sensory characteristics of whipped cream
International Dairy Journal, 2022, 125, 105219
Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization
Cell Reports, 2022, 40 (3), 111120
Characterizing Basal and Feed Media Effects on Mammalian Cell Cultures by Systems Engineering Approaches
IFAC-PapersOnLine, 2022, 55 (7), 31-36
Data-driven and model-guided systematic framework for media development in CHO cell culture
Metabolic Engineering, 2022, 73, 114-123
Nutrient Profiling of Japanese Dishes: The Development of a Novel Ajinomoto Group Nutrient Profiling System
Frontiers in Nutrition, 2022, 9, 912148
A comparative study of swarm intelligence and artificial neural networks applications in modeling complex reaction processes
Computer Aided Chemical Engineering, 2022, 51, 175-180
Effects of dietary leucine and tryptophan on serotonin metabolism and growth performance of growing pigs
Journal of Animal Science, 2022, 100 (1), skab356
Corrigendum to “Lactational performance and plasma and muscle amino acid concentrations in dairy cows fed diets supplying 2 levels of digestible histidine and metabolizable protein” (J. Dairy Sci. 105:170–187) (Journal of Dairy Science (2022) 105(1) (170–187), (S0022030221009620), (10.3168/jds.2021-20800))
Journal of Dairy Science, 2022, 105 (6), 5544
Analytical Chemistry of Impurities in Amino Acids Used as Nutrients: Recommendations for Regulatory Risk Management
Nutrients, 2022, 14 (14), 2838
Erratum: Structural insights into the enhanced thermostability of cysteine substitution mutants of L-histidine decarboxylase from Photobacterium phosphoreum (J. Biochem. (2021) DOI: 10.1093/jb/mvab103)
Journal of Biochemistry, 2022, 171 (5), 599
Sedimentation behavior of suspensions in milliflow reactors
Chemical Engineering Science, 2022, 259, 117794
Development of Burden Scale for Dietary Behavior Appropriate for College Athletes
Asian Journal of Sports Medicine, 2022, 13 (1), e114936
l-Tryptophan-starved cultivation enhances S-allyl-l-cysteine synthesis in various food-related microorganisms
Bioscience, Biotechnology and Biochemistry, 2022, 86 (6), 792-799
Retronasal Aroma of Beef Pate Analyzed by a Chewing Simulator
Molecules, 2022, 27 (10), 3259
Lipocalin 15 in the olfactory mucus is a biomarker for Bowman’s gland activity
Scientific Reports, 2022, 12 (1), 9984
Structural insights into the enhanced thermostability of cysteine substitution mutants of L-histidine decarboxylase from Photobacterium phosphoreum
Journal of Biochemistry, 2022, 171 (1), 31-40
Proposal for a nanocrystalline cellulose pilot plant integrated into a bleached pulp mill using ASPEN PLUS simulation; [PROPOSTA DE PLANTA PILOTO DE CELULOSE NANOCRISTALINA INTEGRADA A UMA FÁBRICA DE POLPA BRANQUEADA UTILIZANDO SIMULAÇÃO EM ASPEN PLUS]
O Papel, 2022, 83 (7), 85-89
Biological Evaluation of Maytansinoid-Based Site-Specific Antibody-Drug Conjugate Produced by Fully Chemical Conjugation Approach: AJICAP®
Frontiers in Bioscience - Landmark, 2022, 27 (8), 234
Practical Ferrioxalate Actinometry for the Determination of Photon Fluxes in Production-Oriented Photoflow Reactors
Organic Process Research and Development, 2022, 26 (8), 2392-2402
Effect of feeding rumen-protected lysine through the transition period on postpartum uterine health of dairy cows
Journal of Dairy Science, 2022, 105 (9), 7805-7819
Soup Consumption Inversely Correlates with the Risk of Obesity: A Systematic Review
ACS Symposium Series, 2022, 1430, 13-21
Lactational performance and plasma and muscle amino acid concentrations in dairy cows fed diets supplying 2 levels of digestible histidine and metabolizable protein
Journal of Dairy Science, 2022, 105 (1), 170-187
Adequate Protein Intake on Comprehensive Frailty in Older Adults: Kyoto-Kameoka Study
Journal of Nutrition, Health and Aging, 2022, 26 (2), 161-168
Dietary risk factors of physical growth of Filipino school-aged children
Food and Nutrition Research, 2022, 66, 7873
Dietary supplementation with branched-chain amino acids enhances milk production by lactating sows and the growth of suckling piglets
Journal of Animal Science and Biotechnology, 2022, 13 (1), 65
Comparative Analysis of Catabolic and Anabolic Dehydroshikimate Dehydratases for 3,4-DHBA Production in Escherichia coli
Identification of the Talaromyces cellulolyticus Gene Encoding an Extracellular Enzyme with β-galactosidase Activity and Testing it as a Reporter for Gene Expression Assays
Molecular Biotechnology, 2022, 64 (6), 637-649
Cystine/Glutamine Mixture Supplementation Attenuated Fatigue during Endurance Exercise in Healthy Young Men by Enhancing Fatty Acid Utilization
Sports, 2022, 10 (10), 147
Preferential freezing avoidance localised in anthers and embryo sacs in wintering Daphne kamtschatica var. jezoensis flower buds visualised by magnetic resonance imaging
Plant Cell and Environment, 2022, 45 (7), 2109-2125
Microbial Production Potential of Pantoea ananatis: From Amino Acids to Secondary Metabolites
Microorganisms, 2022, 10 (6), 1133
Dietary supplementation with monosodium glutamate enhances milk production by lactating sows and the growth of suckling piglets
Amino Acids, 2022, 54 (7), 1055-1068
Cystine and theanine as stress-reducing amino acids—perioperative use for early recovery after surgical stress
Nutrients, 2022, 14 (1), 129
Effects of an essential amino acid mixture on behavioral and psychological symptoms of dementia and executive function in patients with Alzheimer's disease: A double-blind, randomized, placebo-controlled exploratory clinical trial
International Journal of Geriatric Psychiatry, 2022, 37 (9), GPS5782
Single-chain tandem macrocyclic peptides as a scaffold for growth factor and cytokine mimetics
Communications Biology, 2022, 5 (1), 56
Development of a Novel Nutrition-Related Multivariate Biomarker for Mild Cognitive Impairment Based on the Plasma Free Amino Acid Profile
Nutrients, 2022, 14 (3), 637
Hydrogel Formation by Glutamic-acid-based Organogelator Using Surfactant-mediated Gelation
Journal of Oleo Science, 71 (8), 1169-1180
Engineering of Escherichia coli Glyceraldehyde-3-Phosphate Dehydrogenase with Dual NAD+/NADP+ Cofactor Specificity for Improving Amino Acid Production
Microorganisms, 2022, 10 (5), 976
Xeno-Free Materials for Stabilizing Basic Fibroblast Growth Factor and Enhancing Cell Proliferation in Human Pluripotent Stem Cell Cultures
Materials, 2022, 15 (10), 3687
The Properties and Application of Insulating Materials for High Performance IC Package
Journal of Japan Institute of Electronics Packaging, 2022, 25 (3), 204-209
Effects of Five Amino Acids (Serine, Alanine, Glutamate, Aspartate, and Tyrosine) on Mental Health in Healthy Office Workers: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial
Nutrients, 2022, 14 (11), 2357
Erratum to: Structural insights into the enhanced thermostability of cysteine substitution mutants of L-histidine decarboxylase from Photobacterium phosphoreum
Journal of biochemistry, 2022, 171 (4), 471
Low Amino Acid Score of Breakfast is Associated with the Incidence of Cognitive Impairment in Older Japanese Adults: A Community-Based Longitudinal Study
Journal of Prevention of Alzheimer's Disease, 2022, 9 (1), 151-157
Rational design of a disulfide bridge increases the thermostability of microbial transglutaminase
Applied Microbiology and Biotechnology, 2022, 106 (12), 4553-4562
Three enzymes of Rhizobium radiobacter involved in the novel metabolism of two naturally occurring bioactive oxidative derivatives of l-isoleucine
Bioscience, Biotechnology and Biochemistry, 2022, 86 (9), 1247-1254
Enzymatic Conjugation of Modified RNA Fragments by Ancestral RNA Ligase AncT4_2
Applied and Environmental Microbiology, 2022, 88 (23)
Antibody-Drug Conjugate Synthesis Using Continuous Flow Microreactor Technology
Organic Process Research and Development, 2022, 26 (9), 2766-2770
Effects of TUG-891, a potent GPR120 agonist, on the physical and oral lipid- coating properties, and secretion of saliva
Physiology and Behavior, 2023, 265, 114160.
Plasma free amino acid profiles are associated with serum high molecular weight adiponectin levels in Japanese medical check-up population without type 2 diabetes mellitus
Amino Acids, 2023, 55 (5), 639-649.
Tag-Free Antibody Modification Mediated by Lipoic Acid Ligase A: Application to Antibody-Drug Conjugates Production
ChemistrySelect, 2023, 8 (9), e202204706.
Effect of Micellar Shape on Viscoelastic Behavior and Gel Network Structure of Hydrogel Formed by Surfactant-mediated Gelation Using Glutamic-acid-based Organogelator
Journal of Oleo Science, 2023, 72 (6), 613-621.
Enhanced chondrogenic differentiation of iPS cell-derived mesenchymal stem/stromal cells via neural crest cell induction for hyaline cartilage repair
Frontiers in Cell and Developmental Biology, 2023, 11, 1140717.
Physico-chemical and Textural Properties of 3D Printed Plant-based and Hybrid Soft Meat Analogs
Plant Foods for Human Nutrition, 2023.
Salt intake reduction using umami substance-incorporated food: A secondary analysis of NHANES 2017-2018 data
Public Health Nutrition, 2023, 26 (2), 488-495.
Evaluation of starch retrogradation by X-ray diffraction using a water-addition method
LWT, 2023, 173, 114341.
Characterization of a xylanase belonging to the glycoside hydrolase family 5 subfamily 35 from Paenibacillus sp. H2C
Bioscience, Biotechnology and Biochemistry, 2023, 87 (1), 54-62.
Enhanced preference for dried bonito dashi by prior experience with dashi and various taste substances in mice
Physiology and Behavior, 2023, 261, 114084.
Efficient Microfluidic Screening Method Using a Fluorescent Immunosensor for Recombinant Protein Secretions
NANO-MICRO Small, 2023, 19 (34), 2207943
Online SFE-SFC-MS/MS colony screening: A high-throughput approach for optimizing (-)-limonene production
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2023, 1215, 123588.
Screening of α-amino acid ester acyl transferase variant with improved activity by combining rational and random mutagenesis
Journal of Biochemistry, 2023, 173 (1), 43-52.
The influence of serial 50 μL microsampling on rats administered azathioprine, the immunosuppressive drug
Toxicology Reports, 2023, 10, 334-340.
Fatty acid overproduction by gut commensal microbiota exacerbates obesity
Cell Metabolism, 2023, 35 (2), 361-375.
Combination of poly-γ-glutamic acid and galactooligosaccharide improves intestinal microbiota, defecation status, and relaxed mood in humans: a randomized, double-blind, parallel-group comparison trial
Bioscience of Microbiota, Food and Health, 2023, 42 (1), 34-48.
Bacterially Secretable Single-Chain Tandem Macrocyclic Peptides for High Affinity and Inhibitory Activity
ChemBioChem, 2023, 24 (2), e202200599.
Reducing salt intake with umami: A secondary analysis of data in the UK National Diet and Nutrition Survey
Food Science and Nutrition, 2023, 11 (2), 872-882.
AJICAP Second Generation: Improved Chemical Site-Specific Conjugation Technology for Antibody-Drug Conjugate Production
Bioconjugate Chemistry, 2023.
Characteristic changes in plasma glutamate levels and free amino acid profiles in Japanese patients with type 1 diabetes mellitus
Journal of Diabetes Investigation, 2023, 14 (1), 111-121.
School Lunch Programs and Nutritional Education Improve Knowledge, Attitudes, and Practices and Reduce the Prevalence of Anemia: A Pre-Post Intervention Study in an Indonesian Islamic Boarding School
Nutrients, 2023, 15 (4), 1055.
Feeding rumen-protected lysine altered immune and metabolic biomarkers in dairy cows during the transition period
Journal of Dairy Science, 2023, 106 (4), 2989-3007.
Effect of starch retrogradation on molecular dynamics of cooked rice by quasi-elastic neutron scattering
Food Hydrocolloids, 2023, 141, 108728.
Ambient temperature structure of phosphoketolase from Bifidobacterium longum determined by serial femtosecond X-ray crystallography
Modelling of salt intake reduction by incorporation of umami substances into Japanese foods: a cross-sectional study
BMC Public Health, 2023, 23 (1), 516.
The pH-responsive precipitation–redissolution of the CspB fusion protein, CspB50TEV-Teriparatide, triggered by changes in secondary structure
Biochemistry and Biophysics Reports, 2023, 33, 101435.
Acceleration of CRISPR/Cas9-Mediated Editing at Multiple Sites in the Saccharomyces cerevisiae Genome
Methods and Protocols, 2023, 6 (2), 39.
Biopesticide and plant growth-promoting activity in maize distillers' dried grains with solubles
Industrial Crops and Products, 2023, 193, 116175.
Effect of microsampling (50 μL) on toxicological evaluation of methapyrilene, a hepatotoxic substance, in a collaborative 28-day study in female rats
Journal of Toxicological Sciences, 2023, 48 (1).
H+-Translocating Membrane-Bound Pyrophosphatase from Rhodospirillum rubrum Fuels Escherichia coli Cells via an Alternative Pathway for Energy Generation
Microorganisms, 2023, 11 (2), 294.
Development and Application of Analytical Methods for Chiral Amino Acids and Related Metabolites
Chromatography, 2023, 44 (1), 21-26.
A Novel Macrocyclic Peptide Dimer Format toward Construction of a High Throughput Screening System
